Anti-AURKA Recombinant Antibody Products

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Anti-AURKA Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a pioneer in the oncology and cell cycle space, providing world-class anti-Aurora Kinase A (AURKA) recombinant antibodies for functional work. As an enzyme required for cell division, and a validated therapeutic target in cancer, AURKA is a master regulator of mitotic entry and spindle assembly. Our highly specific and validated antibodies are vital reagents to investigate mitosis, aneuploidy, and the response to emerging AURKA inhibitors.

AURKA: A Master Regulator of Mitosis and a Key Cancer Target

AURKA (Aurora Kinase A) is a serine/threonine kinase that orchestrates several checkpoints throughout mitosis. It is involved in centrosome maturation, mitotic spindle assembly, and chromosome segregation. Aurora Kinase A is overexpressed/amplified in the majority of human cancers, including breast, ovarian, and colon cancers. It has been shown to drive chromosomal instability and aneuploidy, both of which are drivers of oncogenesis, and to also promote tumor progression and therapy resistance. As such, AURKA is a prime target in modern drug development for cancer therapeutics.

Alternative Names

Aurora Kinase A; Protein Phosphatase 1, Regulatory Subunit 47; Serine/Threonine-Protein Kinase Aurora-A; Serine/Threonine-Protein Kinase 6; Breast Tumor-Amplified Kinase; Aurora/IPL1-Related Kinase 1; Aurora 2; STK15; STK6; ARK1; AURA; BTAK; AIK; Serine/Threonine Protein Kinase 15; Serine/Threonine-Protein Kinase 15; AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonin

Background

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Anti-AURKA rAb Products

Creative Biolabs' anti-AURKA recombinant antibodies are designed with superior specificity and functionality in mind. Each batch of antibodies is validated to detect the AURKA enzyme in cell lysates and tumor tissue, allowing for accurate assessment of its expression and phosphorylation state. Optimized for Western Blot, IHC, and immunofluorescence applications, these rAbs are designed with the reliability your cancer research demands.

Table 1. Featured anti-AURKA recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, we are committed to supporting the needs of the innovative oncology and cell cycle researcher. Our anti-AURKA recombinant antibodies are produced under a robust quality control program. Each batch is thoroughly tested for purity, specificity to other Aurora kinases (B and C), and performance to ensure you receive the highest quality reagent.

Customer Reviews

Excellent

Le*e
Mouse Anti-AURKA Recombinant Antibody (ZG-0311F)

The anti-AURKA antibody from Creative Biolabs was great for our immunofluorescence studies. We were able to see very clearly the localization of the protein to the centrosomes and spindle poles throughout mitosis. Great product.

09/Sep/2024

Excellent

Ge*e
Rabbit Anti-AURKA Recombinant Antibody (clone 1H8)

We are working on AURKA inhibitors, and this antibody has been crucial in helping us validate target expression and pathway modulation downstream in our cellular models using western blot. The signal is strong and very specific.

29/Feb/2023

rAb Production

Creative Biolabs uses advanced platforms for the production of recombinant antibodies to help move novel cancer therapeutics forward. Our anti-AURKA recombinant antibodies are produced in systems specifically engineered to ensure they are highly specific to the native kinase, which means a more biologically active product for your research.

Featured Anti-AURKA Recombinant Antibody Production Platforms
Fig.4 Milligram-scale anti-AURKA recombinant antibody production.

Fig.5 Gram-scale anti-AURKA recombinant antibody production.

rAb Modalities

Creative Biolabs is here to deliver innovative solutions for oncology researchers. Our anti-AURKA recombinant antibodies are available in a wide range of customizable modalities, including phospho-specific antibodies for monitoring enzyme activity, so researchers across the globe can study this important mitotic kinase.

Fig.6 Full-length anti-AURKA recombinant antibody production and modalities.

Target cell division in cancer with Creative Biolabs' high-quality anti-AURKA recombinant antibodies. Our catalog is designed to meet the needs of today's researcher, providing the specificity and functional activity required to study this important oncogenic kinase. Rely on our experience to provide a strong foundation for next-generation cancer therapeutics. Connect with our scientific team today.