Anti-BCKDK Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides world-class, anti-BCKDK recombinant antibodies to support research into metabolic disease. BCKDK is the rate-limiting kinase that tightly controls branched-chain amino acid (BCAA) catabolism. It is a crucial target in research into maple syrup urine disease (MSUD) and an increasingly important therapeutic target in more prevalent metabolic conditions. Creative's high-quality antibodies are the tools you need to develop a novel therapeutic kinase inhibitor and better understand BCAA metabolism.

BCKDK: The Master Switch for Branched-Chain Amino Acid Breakdown

Branched-Chain Ketoacid Dehydrogenase Kinase (BCKDK) is a mitochondrial enzyme with a single, highly specific role in cells: phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex. BCKDH is the rate-limiting enzyme that drives the catabolic breakdown of the three branched-chain amino acids: leucine, isoleucine, and valine. BCKDK inactivates BCKDH and therefore serves as a master brake on BCAA catabolism. Mutations that result in a loss of BCKDH function cause maple syrup urine disease (MSUD). Hyperactivity of BCKDK resulting in elevated BCAA levels has been shown to be a risk factor in insulin resistance and heart failure. Therefore, inhibition of BCKDK is a promising strategy to drive BCAA catabolism and lower their abundance in metabolic disorders.

Alternative Names

BDK; BCKDKD

Background

The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is a key enzyme that regulates the valine, leucine and isoleucine catabolic pathways. This gene encodes a protein that is located in the mitochondrion and inactivates BCKD by phosphorylation. Several transcript variants encoding different isoforms have been identified for this gene.

Anti-BCKDK rAb Products

Our anti-BCKDK recombinant antibodies are developed to ensure that you receive the highest specificity and most robust performance. Each antibody is fully validated to ensure specific detection of the BCKDK enzyme in mitochondrial lysates from a range of tissues. The rAbs are optimized for Western Blot detection of expression levels and co-immunoprecipitation with its target, the BCKDH complex, to study their interaction.

Table 1. Featured anti-BCKDK recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses the most advanced production platforms to support the highly-specialized area of metabolic research. Our anti-BCKDK recombinant antibodies are produced in highly optimized systems to ensure they specifically recognize the native mitochondrial enzyme, resulting in a highly specific and active antibody for your research.

Featured Anti-BCKDK Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-BCKDK recombinant antibody production.

Fig.2 Gram-scale anti-BCKDK recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting the scientific discoveries of tomorrow. We offer a portfolio of highly specific and flexible antibody solutions, including our anti-BCKDK recombinant antibodies, in a range of customizable modalities to support your experimental needs.

Fig.3 Full-length anti-BCKDK recombinant antibody production and modalities.

Explore the important roles of BCKDK in branched-chain amino acid catabolism with Creative Biolabs' recombinant antibodies. We pride ourselves on our high specificity and comprehensive validation, which ensures our antibodies are the right tools for your research into both rare and common metabolic disease. Choose quality that drives discovery and contact our specialists today.