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BCL11B
Loading...Anti-BCL11B Products
- Rabbit Anti-BCL11B Recombinant Antibody (clone JF09-90) (MRO-0399-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Rabbit Anti-BCL11B Recombinant Antibody (clone 25B6) (FAMAB-1018CQ)
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- Species Reactivity: Guinea Pig, Rat, Zebrafish, Human, Cynomolgus monkey, Mouse
- Type: Rabbit IgG
- Application: IB, IHC
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- Anti-BCL11B Immunohistochemistry Kit (VS-0525-XY725)
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- Species Reactivity: Human
- Target: BCL11B
- Application: IHC
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- Anti-Mouse BCL11B Immunohistochemistry Kit (VS-0525-XY726)
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- Species Reactivity: Human, Mouse
- Target: BCL11B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (T-cells, Inhibitory neurons, Basal squamous epithelial cells, Suprabasal keratinocytes, Basal keratinocytes, Excitatory neurons, NK-cells)
Immune cell specificity
Group enriched (naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell, T-reg, gdT-cell, MAIT T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity). Interacts with EP300; the interaction is detected in activated T-lymphocytes, but not under resting conditions (PubMed:27959755).
Molecular function
Repressor
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