Anti-BIRC3 Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted ally in immunology and cancer research. We provide outstanding anti-BIRC3 (cIAP2) recombinant antibodies to support your work. This E3 ubiquitin ligase and inhibitor of apoptosis (IAP) is a master regulator of the NF-κB pathway and cell survival. Our high-quality antibodies will help you uncover the role of inflammatory signaling, cancer pathogenesis, and potential therapeutic interventions such as SMAC mimetics.

BIRC3: A Critical Node in NF-κB Signaling and Cell Survival

Baculoviral IAP Repeat Containing 3 (BIRC3), also known as cellular IAP2 (cIAP2), is a member of the IAP family. It is a weaker direct inhibitor of caspases compared to some other IAPs, but it functions primarily as an E3 ubiquitin ligase in the TNF receptor signaling complex. BIRC3 is a critical activator of the non-canonical NF-κ-B pathway and a regulator of the canonical pathway. Both pathways are central to the control of inflammation, immunity, and cell survival. Certain lymphomas and leukemias exhibit frequent deletion or mutation of BIRC3. These cancers are often dependent on constitutive NF-κ-B activation for survival.

Alternative Names

BIRC3; CIAP2; IAP-1; MALT2; API2; TNFR2-TRAF Signaling Complex Protein; Baculoviral IAP Repeat Containing 3; HIAP1; TNFR2-TRAF-Signaling Complex Protein 1; AIP1; Baculoviral IAP Repeat-Containing 3; IAP1; MIHC; HIAP-1; Mammalian IAP Homolog C; C-IAP2; RIN

Background

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Anti-BIRC3 rAb Products

Creative Biolabs' anti-BIRC3 recombinant antibodies are produced for optimal specificity and performance. They are carefully validated to accurately detect BIRC3 protein without cross-reactivity with its close homolog BIRC2 (cIAP1). Our recombinant antibodies are optimized for applications such as Western Blot to monitor protein levels and co-immunoprecipitation to study BIRC3-containing signaling complexes. The rAbs offer the stability and reliability your research requires.

Table 1. Featured anti-BIRC3 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to helping you achieve scientific success through products of the highest quality. Production of our anti-BIRC3 recombinant antibodies is guided by strict quality assurance protocols. Every lot of rAbs is tested for purity, isoform specificity, and validated performance in your applications. Place your order with confidence and receive a high-quality reagent that will give you clean, reproducible data.

Customer Reviews

rAb Production

Creative Biolabs has leveraged cutting-edge production platforms to meet the needs of signal transduction research. Our anti-BIRC3 recombinant antibodies are expressed in systems that have been optimized to generate antibodies that will recognize the native protein. This ensures a specific and active antibody for your experiments.

Featured Anti-BIRC3 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-BIRC3 recombinant antibody production.

Fig.3 Gram-scale anti-BIRC3 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering discovery by providing a diverse range of flexible antibody modalities. Our anti-BIRC3 recombinant antibodies are available in multiple customizable formats. We are committed to supporting your investigation of this important regulator of cell survival and inflammation.

Fig.4 Full-length anti-BIRC3 recombinant antibody production and modalities.

Explore the critical role of BIRC3 in NF-κB signaling and cancer with Creative Biolabs' recombinant antibodies. Our products are hallmarked by high specificity and robust validation, making them the ideal tools for your research. Choose a partner that puts quality at the forefront to accelerate discovery. Contact our experts today.