Anti-BIRC5 Recombinant Antibody Products

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Anti-BIRC5 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a front-runner in cancer research, offering a full range of top-quality anti-BIRC5 (Survivin) recombinant antibodies. As a novel protein that is highly expressed in tumors but practically absent in normal adult tissues, Survivin has become a paradigm of cancer targets. Our robust and reliable antibodies are powerful tools to study its dual anti-apoptotic and mitotic functions, as well as for designing novel, tumor-selective therapies.

BIRC5: A Cancer-Specific Regulator of Life and Death

Baculoviral IAP Repeat Containing 5 (BIRC5), also known as Survivin, is the smallest member of the family of inhibitor of apoptosis proteins (IAPs). This molecule is critically important in cancer, where it performs two major functions. First, it can directly inhibit the activity of caspases to block apoptosis. Second, as part of the chromosomal passenger complex (along with AURKB), BIRC5 is important for regulating microtubule dynamics and thus proper cell division. Expression of BIRC5 is very high during embryonic development but silenced in most terminally differentiated adult tissues. Dramatic re-expression in almost all human cancers and near absence from normal adult tissues makes it a perfect, highly selective target for cancer therapy.

Alternative Names

Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; API4 IAP4

Background

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Anti-BIRC5 rAb Products

Our recombinant antibodies to BIRC5 are designed and validated for maximum specificity and sensitivity, so you can detect Survivin reliably in tumor samples. They are rigorously tested to perform in demanding applications, such as IHC for testing prognostic value and flow cytometry for studying cell cycle-dependent expression. With these rAbs, you have the specificity and sensitivity to advance your oncology research with high impact.

Table 1. Featured anti-BIRC5 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs' commitment to the future of cancer research is evident in our stringent quality control. We validate each batch of our anti-BIRC5 recombinant antibody product for purity, binding affinity, and reproducible performance. We want you to know you'll always receive a high-quality reagent with consistent performance that meets the precise demands of working with one of the best cancer targets out there.

Customer Reviews

Excellent

Ha***h
Rabbit Anti-BIRC5 Recombinant Antibody (clone 6G11)

The anti-Survivin antibody from Creative Biolabs was excellent for our IHC analysis of patient tumor samples. The staining was extremely clean and specific to the tumor cells.

04/Feb/2024

Excellent

Na***n
Recombinant Anti-human BIRC5 VHH Single Domain Antibody

We used this antibody for immunofluorescence and it beautifully co-localized with the mitotic spindle, allowing us to study this protein's role in cell division. An excellent product.

11/Aug/2024

rAb Production

Creative Biolabs is always working to help accelerate progress in oncology research. We use the latest antibody production platforms so that our anti-BIRC5 recombinant antibodies are expressed in highly optimized systems to be sure they correctly recognize the native protein in its various subcellular locations. We are committed to delivering a product that is highly biologically relevant and active.

Featured Anti-BIRC5 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-BIRC5 recombinant antibody production.

Fig.3 Gram-scale anti-BIRC5 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to meeting your needs with flexibility and innovation. Our recombinant antibodies to BIRC5 (Survivin) are available in a variety of customizable modalities to support researchers around the world to learn more about this important, cancer-specific protein and to develop targeted therapies.

Fig.4 Full-length anti-BIRC5 recombinant antibody production and modalities.

Explore Survivin's dual roles in cancer with the precision of Creative Biolabs' recombinant antibodies. Our products are characterized by rigorous validation and unmatched consistency to provide you with the very best tools to study this key oncogenic protein. Partner with us for quality that powers progress. Contact our specialists today.