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BNIP3
Anti-BNIP3 Recombinant Antibody Products
- Rabbit Anti-BNIP3 Recombinant Antibody (clone JA71-10) (MRO-0187-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Mouse Anti-BNIP3 Recombinant Antibody (clone BOb50) (MOB-1506MZ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, ICC, IP, WB
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For Research Use Only. Not For Clinical Use.
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation.
Protein class
Cancer-related genes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Extravillous trophoblasts, Hepatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431, hTERT-RPE1, U-87 MG)
Interaction
Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization (PubMed:15868100). (Microbial infection) Interacts with adenovirus E1B 19 kDa protein. (Microbial infection) Interacts with Epstein-Barr virus BHRF1.
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