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BNIP3

Anti-BNIP3 Products

Rabbit Anti-BNIP3 Recombinant Antibody (clone JA71-10) (MRO-0187-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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Mouse Anti-BNIP3 Recombinant Antibody (clone F7-A5) (VS3-WK89)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA
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Recombinant Rabbit Anti-BNIP3 Antibody (clone R09-1G8) (VS3-FY163)
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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Mouse Anti-BNIP3 Recombinant Antibody (clone BOb50) (MOB-1506MZ)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, ICC, IP, WB
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Hi-Affi™ Rabbit Anti-BNIP3 Recombinant Antibody (clone DS374AB) (MOR-0374)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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Hi-Affi™ Rabbit Anti-BNIP3 Recombinant Antibody (clone TH2DS) (MOR-4494)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, ICC
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Mouse Anti-BNIP3 Recombinant Antibody (clone 4E11F4) (VS7-HM250)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, FCM
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Rabbit Anti-BNIP3 Recombinant Antibody (VS13-YC104) (VS13-YC104)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P
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Anti-BNIP3 Immunohistochemistry Kit (VS-0525-XY811)
- Species Reactivity: Human
- Target: BNIP3
- Application: IHC
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More Infomation

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For Research Use Only. Not For Clinical Use.

Background

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation.

Protein class

Cancer-related genes, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Extravillous trophoblasts, Hepatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A-431, hTERT-RPE1, U-87 MG)

Interaction

Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization (PubMed:15868100). (Microbial infection) Interacts with adenovirus E1B 19 kDa protein. (Microbial infection) Interacts with Epstein-Barr virus BHRF1.

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