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BNIP3

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation.
Protein class

Cancer-related genes, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Extravillous trophoblasts, Hepatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A-431, hTERT-RPE1, U-87 MG)

Interaction

Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization (PubMed:15868100). (Microbial infection) Interacts with adenovirus E1B 19 kDa protein. (Microbial infection) Interacts with Epstein-Barr virus BHRF1.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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