Anti-C4BPB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs can assist you with your complement and coagulation research with anti-C4BPB recombinant antibodies that provide high specificity and rigorous validation for the beta-chain of the C4b-binding protein complex, C4BPB. C4BPB links complement regulation to the coagulation system. The high-quality antibodies we produce can be invaluable research tools for exploring the crosstalk between these two key plasma systems, which is of growing importance in thrombosis, infection, and inflammation.

C4BPB: Linking Complement Regulation to Vitamin K-Dependent Proteins

Complement Component 4 Binding Protein Beta (C4BPB) is a small chain that is incorporated into a subset of C4BP complexes present in plasma. While the alpha-chains (C4BPA) inhibit the complement system, the beta-chain serves a unique and critical role: it binds to the vitamin K-dependent anticoagulant Protein S. This not only serves to anchor the complement-regulatory activity of the complex, but it also serves to create a direct, molecular connection between the complement and coagulation cascades.

Alternative Names

C4BPB; C4b-Binding Protein Beta Chain; Complement Component 4-Binding Protein, Beta; Beta Chain; Complement Component 4 Binding Protein; C4b Binding Protein

Background

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway.

Anti-C4BPB rAb Products

Creative Biolabs' anti-C4BPB recombinant antibodies are designed for high specificity and are validated for their ability to recognize the beta-chain of the C4BP complex without cross-reactivity with the much more abundant alpha-chain, which is critical for exploring the role of beta-chain-containing isoforms of C4BP. Optimized for Western Blot and ELISA applications, these rAbs can be a dependable, unambiguous option for researchers.

Table 1. Featured anti-C4BPB recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs' state of the art production platforms were developed to support hematology and other specialized fields. Our anti-C4BPB recombinant antibodies are produced in highly optimized systems, allowing us to express a product that most faithfully recognizes the native protein, to create a final reagent that is both specific and active for your most demanding applications.

Featured Anti-C4BPB Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C4BPB recombinant antibody production.

Fig.2 Gram-scale anti-C4BPB recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to enabling the work of researchers around the world by making our antibody production as flexible as possible. Anti-C4BPB recombinant antibodies are available in a variety of formats that are customizable to meet the unique needs of your experiments.

Fig.3 Full-length anti-C4BPB recombinant antibody production and modalities.

Decode complement and coagulation crosstalk with the help of Creative Biolabs' anti-C4BPB recombinant antibodies. Our portfolio of rigorously validated reagents is specifically designed to explore this linking protein with high specificity and reliability. Trust our experience and partner with us to provide a solid foundation for your research. Contact our scientific team today.