Anti-C9 Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in complement research, and we’re proud to offer some of the highest-quality anti-C9 recombinant antibodies available. Complement C9 is the final protein in the complement cascade, and, as the pore-forming unit of the membrane attack complex (MAC), it is the main cell-killing effector of this pathway. Our high-quality antibodies are the ideal tools for studying autoimmune-mediated cell lysis, host defense against infectious disease, and next-generation complement inhibitors.

C9: The Pore-Forming Unit of the Complement System

Complement C9 is the final component of the complement cascade. Following insertion of the C5b-8 complex into the target membrane, C9 binds to its polypentapeptide binding site and undergoes a rapid polymerization event. 10-18 copies of C9 insert and polymerize into a large, ring-shaped pore, the Membrane Attack Complex (MAC). This pore disrupts the osmotic integrity of the cell, causing rapid lysis and death. In addition to its importance in killing bacteria, unregulated MAC formation on self-cells is a major contributor to tissue damage in diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Alternative Names

C9; Complement Component C9; Complement Component 9; ARMD15

Background

This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency.

Anti-C9 rAb Products

Creative Biolabs’ anti-C9 recombinant antibodies are engineered to have high affinity and specificity. They are also extensively validated to recognize both soluble C9 and polymerized C9 within the MAC. Optimized for IHC to visualize deposition of the MAC in diseased tissue (a clear indicator of complement attack) and for functional assays, our rAbs are among the best tools for complement research.
Table 1. Featured anti-C9 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To help move the field of immunology forward, Creative Biolabs uses the latest production platforms to provide you with high-quality reagents. Our anti-C9 recombinant antibodies are expressed in systems that have been optimized to allow proper folding of the target protein and recognition of the native protein, ensuring high functional activity for your research.

Featured Anti-C9 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C9 recombinant antibody production.

Fig.2 Gram-scale anti-C9 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering flexible, innovative solutions for researchers studying disease. Our anti-C9 recombinant antibodies are available in a variety of customizable modalities, including highly functional blocking clones, to help researchers around the world study this important pathway.

Fig.3 Full-length anti-C9 recombinant antibody production and modalities.

Study the last step of cell lysis in the complement cascade with the accuracy of Creative Biolabs’ recombinant antibodies. Defined by strict validation and functional activity, our portfolio of antibodies are the ideal tools to explore this important target in autoimmunity and infectious disease. Partner with us for quality that powers progress. Get in touch with our specialists today.