Anti-CA8 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is committed to supporting the neuroscience community by providing the highest quality anti-CA8 recombinant antibodies. Carbonic Anhydrase-Related Protein 8 (CA8) is a catalytically inactive member of the carbonic anhydrase family that has been linked to the control of motor coordination. Our high-quality antibodies will help you to understand the molecular mechanisms underlying hereditary ataxia and further the study of the non-enzymatic functions of this unique family of proteins in the cerebellum.

CA8: An Acatalytic Player in Cerebellar Function

Carbonic Anhydrase-Related Protein 8 (CA8) belongs to the alpha-carbonic anhydrase family of proteins but it lacks the histidine residues that coordinate a zinc ion, the active site of the carbonic anhydrase enzyme, which makes it catalytically inactive. It is postulated that it may have scaffolding protein or signaling modulator functions instead. This protein is highly expressed in the cerebellar Purkinje cells, which are specialized neurons responsible for motor control and learning. Mutations that inactivate CA8 function result in a type of congenital ataxia, suggesting that this acatalytic family member plays an essential non-catalytic role for normal Purkinje cell signaling and survival and is a critical target for neurobiological study.

Alternative Names

CALS; CARP; CA-RP; CAMRQ3; SCAR34; CA-VIII

Background

The protein encoded by this gene was originally called CA-related protein based on sequence similarity to other previously known carbonic anhydrase genes. However, this gene product does not have carbonic anhydrase activity (i.e. the catalysis of the reversible hydration of carbon dioxide). Nevertheless, the gene product still has a carbonic anhydrase designation based on obvious sequence identity with other members of the carbonic anhydrase gene family. Failure to detect transcription of the CA8 gene in the cerebellum of the lurcher mutant, a mouse that has a neurologic defect, points to a possible significant role for this acatalytic form of the protein. Mutations in this gene have been found to cause cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3).

Anti-CA8 rAb Products

Our anti-CA8 recombinant antibodies are produced with high specificity, and they are thoroughly validated to specifically detect the CA8 protein, with no cross-reactivity to other carbonic anhydrase isoforms. This specificity is critical to your studies to ensure that you are accurately studying the unique functions of this protein in the brain. Optimized for IHC on cerebellar tissue sections as well as Western Blot, our rAbs provide crisp, reproducible results that you can trust for your research.

Table 1. Featured anti-CA8 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to supporting the neuroscience research community by using the latest production technologies to offer the best possible antibodies for your research. Our anti-CA8 recombinant antibodies are produced in systems that have been optimized to ensure the correct expression of the antibody so it will recognize the native protein with high specificity and provide you with a highly specific and active research tool.

Featured Anti-CA8 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CA8 recombinant antibody production.

Fig.2 Gram-scale anti-CA8 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to supporting scientific discovery by providing researchers with flexible, high-quality antibody solutions. Our anti-CA8 recombinant antibodies are available in a variety of customizable modalities to help researchers around the world study this unique signaling modulator.

Fig.3 Full-length anti-CA8 recombinant antibody production and modalities.

Explore the important functions of CA8 with Creative Biolabs' recombinant antibodies. Our product line is characterized by its specificity and thorough validation, providing the right tools for your research into ataxia and neuronal signaling. Choose a partner that will help speed up your discoveries. Contact our experts today.