Anti-CALM1 Products

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For Research Use Only. Not For Clinical Use.

Signal transduction and cardiovascular biology research just got a whole lot easier with Creative Biolabs' highly specific anti-CALM1 recombinant antibodies. CALM1 is the ubiquitous calcium sensor protein that regulates virtually all aspects of cell biology. The need for excellent tools to study calcium signaling in the myriad of cellular contexts is so fundamental and diverse it ranges from neurotransmission to cardiac arrhythmias and everything in between.

CALM1: The Ubiquitous Calcium Sensor

Calmodulin 1 (CALM1) is one of three genes (CALM1, CALM2, and CALM3) that encode the same, ubiquitously expressed, and truly indispensable calcium-binding protein, calmodulin. Calmodulin is a small (approximately 17kD) dumbbell-shaped protein that has four EF-hand motifs that bind calcium. When calcium binds to calmodulin, it induces a large conformational change in the protein that allows it to bind to (and regulate the activity of) hundreds of downstream effector proteins, including protein kinases (e.g., CaMKII), phosphatases (e.g., calcineurin), and ion channels. Calmodulin is the primary and most important transducer of calcium signals in all eukaryotic cells. Mutations in any of the calmodulin genes lead to severe, often life-threatening cardiac arrhythmias.

Alternative Names

Calmodulin; CaM; CALcium-MODULated proteIN

Background

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.

Anti-CALM1 rAb Products

Our recombinant anti-calmodulin antibodies are engineered for high affinity and high performance. Because the protein products of CALM1, CALM2, and CALM3 are identical, our antibodies recognize all three genes. They are extensively validated for nearly every application, including Western Blot, IHC, immunofluorescence, and immunoprecipitation, and offer a well-optimized and reliable tool for studying this key signaling protein in any system.

Table 1. Featured anti-CALM1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to providing optimal tools for the entire field of cell biology and we utilize cutting edge production platforms to do so. Our recombinant anti-calmodulin antibodies are expressed in systems that are optimized to ensure they accurately recognize the native protein in both its apo- and calcium-bound forms.

Featured Anti-CALM1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CALM1 recombinant antibody production.

Fig.2 Gram-scale anti-CALM1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your scientific endeavors by providing the most flexible antibody solutions possible. Our anti-calmodulin recombinant antibodies are available in a wide range of formats and conjugations to fit any experimental need from basic detection all the way to advanced microscopy.

Fig.3 Full-length anti-CALM1 recombinant antibody production and modalities.

You want to know how the most basic aspects of your model system work? You need to study calcium signaling? We've got you covered! Creative Biolabs has the breadth of rigorously validated and consistent anti-calmodulin recombinant antibodies to help you get to the bottom of this universal signaling protein. Trust us to give you a solid foundation to your research. Contact our scientific team today.