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CCN2

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Protein class

Cancer-related genes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Fibroblasts, Smooth muscle cells, Adipocytes, Extravillous trophoblasts, Cardiomyocytes)

Immune cell specificity

Immune cell enriched (naive B-cell)

Cell line specificity

Cell line enhanced (EFO-21, HUVEC TERT2, TIME)

Interaction

Monomer (PubMed:1654338). Interacts with TSKU (PubMed:30232710).

Molecular function

Heparin-binding

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