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    CD3G

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    More Infomation

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    For Research Use Only. Not For Clinical Use.


    Background

    CD3G: Encodes a gamma chain of the CD3 complex in T cells. It is critical for T-cell receptor assembly and signaling. The protein regulates T-cell activation and proliferation. Deficiency leads to severe immunodeficiency.
    Protein class

    CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (T-cells, dendritic cells)

    Immune cell specificity

    Group enriched (naive CD8 T-cell, gdT-cell, T-reg, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell)

    Cell line specificity

    Group enriched (JURKAT, MOLT-4)

    Interaction

    The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

    Molecular function

    Receptor

    More Types Infomation
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