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CDH10

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.
Predicted location

Membrane

Single cell type specificity

Group enriched (Oligodendrocyte precursor cells, Excitatory neurons, Inhibitory neurons, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, HAP1, hTERT-RPE1, SuSa)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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