Anti-CENPE Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Purpose-built for your cell division research, our anti-CENPE recombinant antibodies are highly specific tools for studying Centromere Protein E (CENPE), a kinesin motor protein critical for chromosome alignment during mitosis. Ideal for probing the mechanics of cell division, our high-quality anti-CENPE antibodies can also be used to explore CENPE as a promising target for anti-cancer drugs.

CENPE: A Mitotic Kinesin for Chromosome Congression

Centromere Protein E (CENPE) is a plus-end-directed kinesin motor protein that localizes specifically to the kinetochores of chromosomes during mitosis. The kinetochore is the protein structure on a chromosome that attaches to the microtubules of the mitotic spindle during cell division. CENPE facilitates the movement of the attached chromosome toward the metaphase plate, or center, of the dividing cell. This action, called chromosome congression, is an essential process that ensures all chromosomes are properly aligned on the metaphase plate. Chromosome congression is a prerequisite for chromosomes to be evenly segregated into the two daughter cells.

Alternative Names

CENPE; Centromere Protein E; CENP-E; Regulatory Subunit 61; Centromere-Associated Protein E; Kinesin Family Member 10; Centromere Autoantigen E (312kD); Protein Phosphatase 1; Centromere Protein E (312kD); Protein Phosphatase 1, Regulatory Subunit 61; PPP

Background

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.

Anti-CENPE rAb Products

Creative Biolabs’ anti-CENPE recombinant antibodies are designed for maximum specificity and performance. They are stringently validated to specifically detect the target of interest, CENPE. Optimized for use in applications such as immunofluorescence for visualization of its dynamic localization on kinetochores during mitosis or Western Blot to detect its cell cycle-dependent expression, our rAbs are rigorously tested to provide consistency and performance for your cell biology research.

Table 1. Featured anti-CENPE recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs specializes in cell cycle research and uses an optimized, cutting-edge production platform to provide high-quality anti-CENPE recombinant antibodies for your research. Our anti-CENPE rAbs are expressed in systems that are optimized to produce antibodies that closely recognize the native motor protein for a highly specific reagent for your cell division studies.

Featured Anti-CENPE Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CENPE recombinant antibody production.

Fig.2 Gram-scale anti-CENPE recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about enabling scientific research and exploration. To give researchers the most flexibility in their work, our anti-CENPE recombinant antibodies are available in a variety of modalities to meet the needs of your experimental design. Creative Biolabs is here to help researchers across the globe to study this important mitotic motor.

Fig.3 Full-length anti-CENPE recombinant antibody production and modalities.

Dissect chromosome alignment with Creative Biolabs’ anti-CENPE recombinant antibodies. Our validated portfolio and consistency offer researchers a solid foundation for investigating this important anti-mitotic drug target. Let our experience be your guide, and contact a member of our scientific team today.