Anti-CHAT Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

The anti-CHAT recombinant antibodies from Creative Biolabs are highly specific and of the highest quality to support your neuroscience research. Choline Acetyltransferase (CHAT) is the enzyme that catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) in cholinergic neurons and is considered a definitive marker for this population of neurons. Our top-quality anti-CHAT antibodies will help you map the cholinergic circuits of the brain or study neurodegenerative conditions like Alzheimer’s and motor neuron disease.

CHAT: The Acetylcholine-Synthesizing Enzyme

Choline acetyltransferase (CHAT) is a soluble, cytoplasmic enzyme that is expressed exclusively in cholinergic neurons. Its only known function is the synthesis of the neurotransmitter acetylcholine (ACh) by catalyzing the transfer of an acetyl group from acetyl-CoA to choline. Newly synthesized ACh is then loaded into synaptic vesicles, transported into the presynaptic terminal, and released in response to an action potential. Cholinergic neurons have a variety of roles in the nervous system, including activation of skeletal muscle at the neuromuscular junction, and involvement in memory, learning, and attention. Cholinergic neuron loss and dysfunction is one of the hallmarks of Alzheimer’s disease and cholinergic neuron loss in the spinal cord results in paralysis in motor neuron disease.

Alternative Names

CHAT; Acetyl CoA:Choline O-Acetyltransferase; EC 2.3.1; CMS1A2; CHOACTASE; EC 2.3.1.6; Choline Acetyltransferase; Choline Acetylase; CMS1A; ChAT

Background

Enables choline O-acetyltransferase activity and choline binding activity. Involved in several processes, including acetylcholine biosynthetic process; antral ovarian follicle growth; and response to ethanol. Located in neuron projection. Biomarker of Alzheimer's disease and asthma. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).

Anti-CHAT rAb Products

Anti-CHAT recombinant antibodies from Creative Biolabs are the gold standard for defining cholinergic neurons. Developed for maximum specificity and performance in IHC and immunofluorescence applications, our antibodies are carefully validated to give a clean, robust signal in the cytoplasm of cholinergic neurons in the basal forebrain, striatum, and spinal cord, providing a reliable tool for neuroanatomical studies.

Table 1. Featured anti-CHAT recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses advanced production platforms to serve the specialized needs of the neuroscience community. Our anti-CHAT recombinant antibodies are expressed in systems that have been optimized to ensure that they are recognizing the native enzyme and that the antibodies will be a highly specific and active tool for even your most critical experiments.

Featured Anti-CHAT Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CHAT recombinant antibody production.

Fig.2 Gram-scale anti-CHAT recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting and enabling science by offering flexible antibody solutions. Our anti-CHAT recombinant antibodies are available in multiple formats and conjugations to meet a wide range of experimental requirements, providing researchers all over the world with the tools to study the cholinergic system.

Fig.3 Full-length anti-CHAT recombinant antibody production and modalities.

Probe the cholinergic nervous system with high-precision anti-CHAT recombinant antibodies from Creative Biolabs. Our portfolio of validated, high-quality tools will give you the consistency and confidence you need to study this important population of neurons. Trust Creative Biolabs to provide a strong foundation for your research. Contact our scientific team today.