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CHKA
Anti-CHKA Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids, Oligodendrocytes, Astrocytes)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (SK-MEL-30)
Interaction
Homodimer (PubMed:34077757, PubMed:17007874, PubMed:20299452). Heterodimer with CHKB (By similarity). [Isoform 1]: Monomer; acetylation by KAT5 promotes dissociation of the homodimer and monomerization. (Microbial infection) Interacts with PI4KA/PI4KIIIalpha; CHKA bridges PI4KA/PI4KIIIalpha and hepatitis C virus (HCV) non-structural protein 5A (NS5A) and potentiates NS5A-stimulated PI4KA activity, which then facilitates the targeting of the ternary complex to the ER for viral replication.
Molecular function
Kinase, Transferase
More Types Infomation
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