Anti-CHKA Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leading source for oncology and lipid metabolism research reagents, providing premium anti-CHKA recombinant antibodies. Choline Kinase Alpha (CHKA), the first and rate-limiting enzyme of the Kennedy pathway for phosphatidylcholine synthesis, is often overexpressed in cancers. We provide high-quality, isoform-specific antibodies to study its function as an oncogene and an emerging therapeutic target.

CHKA: A Key Enzyme in Membrane Synthesis and Cancer

Choline kinase alpha (CHKA) is a cytosolic enzyme that phosphorylates choline using ATP to produce phosphocholine. This is the first and committed step in the CDP-choline or Kennedy pathway, the predominant pathway for the de novo synthesis of phosphatidylcholine (PC), the most common phospholipid of eukaryotic cell membranes. Rapidly proliferating cancer cells have an enormous demand for new membranes and therefore often upregulate this pathway. CHKA is overexpressed in a broad spectrum of human cancers and its high activity is required not only to build membranes but also generates phosphocholine, which acts as a signaling molecule to promote cell growth.

Alternative Names

CHKA; EC 2.7.1.32; CHETK-Alpha; CK; EC 2.7.1.82; EK; Choline Kinase Alpha; CKI; Choline Kinase; CHK; Ethanolamine Kinase

Background

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.

Anti-CHKA rAb Products

Our anti-CHKA recombinant antibodies are engineered for high isoform specificity, carefully validated to detect the alpha isoform without cross-reactivity with the closely related Choline Kinase Beta (CHKB). This isoform specificity is crucial for accurately studying its oncogenic role. Optimized for Western Blot and IHC for the evaluation of tumor expression, our rAbs are among the best tools for cancer research.

Table 1. Featured anti-CHKA recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs employs the latest technology in recombinant antibody production to help advance cancer research. Our anti-CHKA recombinant antibodies are carefully crafted to give the highest possible isoform specificity and sensitivity for detection of this important metabolic oncogene.

Featured Anti-CHKA Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CHKA recombinant antibody production.

Fig.2 Gram-scale anti-CHKA recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing flexible and innovative research tools for the scientific community. Our anti-CHKA recombinant antibodies are available in many modalities to support a wide variety of experimental approaches to study this important enzyme.

Fig.3 Full-length anti-CHKA recombinant antibody production and modalities.

Move cancer metabolism research forward with Creative Biolabs’ premium anti-CHKA recombinant antibodies. We pride ourselves on the exceptional specificity and thorough validation of our antibody portfolio, providing the best tools for cancer drug discovery and fundamental research into the biology of cancer. We are experts in what we do so trust us to help support your important work. Contact our scientists today.