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CHL1

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For Research Use Only. Not For Clinical Use.


Enables protease binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including adult locomotory behavior; exploration behavior; and generation of neurons. Located in apical part of cell and dendrite. Is expressed in head mesenchyme; nervous system; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHL1 (cell adhesion molecule L1 like).
Protein class

Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Excitatory neurons, Inhibitory neurons, Astrocytes)

Immune cell specificity

Group enriched (naive B-cell, memory B-cell)

Cell line specificity

Group enriched (SK-MEL-30, WM-115)

Interaction

May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3 (By similarity).

Molecular function

Developmental protein

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