1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Anti-CKM Recombinant Antibody Products

    Loading...

    Anti-CKM Products

    + Filter
    Loading...
    View More Products

    Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

    More Infomation

    Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

    For Research Use Only. Not For Clinical Use.


    Creative Biolabs is your trusted partner in musculoskeletal and cardiovascular research, with our line of premier anti-CKM recombinant antibodies. The muscle-specific isoform of creatine kinase (CKM), this enzyme is responsible for fueling muscle contraction. High-quality, isoform-specific antibodies from Creative Biolabs are critical reagents for research applications involving muscle physiology, Duchenne muscular dystrophy, and as a gold-standard diagnostic marker for myocardial infarction.

    CKM: The Muscle-Specific Creatine Kinase

    Creatine kinase, muscle (CKM) is a cytosolic dimeric enzyme that can comprise up to 20% of the soluble protein in skeletal muscle. This enzyme is necessary to maintain energy homeostasis during periods of high demand in active muscles. Creatine kinase functions in energy metabolism by using phosphocreatine to rapidly re-synthesize ATP from ADP in the vicinity of where it is needed: at the myosin head, directly fuelling short bursts of high power output. When muscle tissue is damaged (Duchenne muscular dystrophy) or dies (myocardial infarction/heart attack), CKM (and CKB, which together form the CK-MB dimer in the heart) leak into the bloodstream and measurement of their levels in the blood is one of the pillars of clinical diagnostics.

    Alternative Names

    Creatine Kinase, M-Type; Creatine Kinase, Muscle; Creatine Kinase M Chain; EC 2.7.3.2; CKMM; M-CK; Creatine Kinase M-Type; EC 2.7.3; CKM; CKMM; Creatine kinase M; Creatine kinase M chain; Creatine kinase M type; Creatine kinase M-type; Creatine kinase muscle; Creatine kinase, muscle type; KCRM_HUMAN; M-CK; MCK; Muscle creatine kin

    Background

    The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.

    Protein class

    Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enriched (Cardiomyocytes)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enriched (SCLC-21H)

    Interaction

    Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

    Molecular function

    Kinase, Transferase

    More Types Infomation

    Anti-CKM rAb Products

    Our anti-CKM recombinant antibodies are designed to be isoform-specific and are carefully validated to specifically recognize the muscle isoform without cross-reactivity with the brain (CKB) isoform. This is critical to being able to design diagnostic assays (CK-MB) that can distinguish whether damage has occurred to the skeletal muscle or to the cardiac muscle. Optimized for ELISA, Western Blot and IHC, Creative Biolabs’ rAbs represent the best diagnostic-grade reagents available.

    Table 1. Featured anti-CKM recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    ZG-0428F Mouse Anti-CKM Recombinant Antibody (ZG-0428F) Human Mouse IgG ELISA
    MHH-213 Recombinant Human Anti-human CKM Antibody Human Human IgG FC, Neut, Funcs
    PABL-377 Recombinant Mouse Anti-CKM Antibody (MAK33) Human Mouse IgG WB, ELISA, FuncS

    Customer Reviews

    Excellent
    D**el
    Recombinant Mouse Anti-CKM Antibody (MAK33)
    We are looking at muscular dystrophy, and the antibody works great for Western blots and allows us to look at the amount of CKM that remains in diseased muscle tissue.
    25/Feb/2023

    rAb Production

    Creative Biolabs embraces advanced production technologies to help drive research and diagnostics forward. Anti-CKM recombinant antibodies are rigorously developed and screened to deliver the highest-purity, isoform-specific reagents needed for sensitive diagnostic assays.

    Featured Anti-CKM Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
    Fig.1 Milligram-scale anti-CKM recombinant antibody production.

    Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-CKM recombinant antibody production.

    rAb Modalities

    Creative Biolabs is dedicated to providing you with flexible and cutting-edge tools for your research. Our anti-CKM antibodies are available in a number of formats, including matched pairs for use in sandwich ELISAs, to meet your diverse diagnostic and research needs.

    Fig.3 CKM antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-CKM recombinant antibody production and modalities.

    Speed progress in your diagnostic and muscle research with Creative Biolabs’ elite anti-CKM recombinant antibodies. Defined by our unparalleled isoform-specificity and rigorous validation, these reagents are the ideal tools for your most sensitive assays. Rely on our quality and service to support your critical work. Contact our specialists today.

    Go to compare

    Go to compare