Anti-CKMT1A Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted provider of state-of-the-art anti-CKMT1A recombinant antibodies for your cell biology and metabolism research. CKMT1A is the “ubiquitous” isoform of mitochondrial creatine kinase, an enzyme involved in the fundamental bioenergetics of many cell types, including the brain and cancer. Our highly specific and validated antibodies are powerful research tools to study this essential component of mitochondrial energy transport and its dysregulation in disease.

CKMT1A: The Ubiquitous Mitochondrial Creatine Kinase

Mitochondrial Creatine Kinase 1A (CKMT1A), also known as CKMT1 or MIT-CKMT1, is one of two mitochondrial isoforms (the other being the heart and skeletal muscle-specific CKMT2). CKMT1A is expressed ubiquitously in many non-heart or skeletal muscle tissues, including the brain, kidney, and intestine. Like CKMT2, this enzyme is localized in the mitochondrial intermembrane space and uses newly synthesized ATP to produce phosphocreatine, which is then transported to the cytosol. This reaction is essential to establish an energy reserve to buffer highly energetic or fluctuating cell processes. It is also highly expressed in some cancers, likely conferring an ability to maintain energy homeostasis under metabolic stress.

Alternative Names

Creatine Kinase, Mitochondrial 1A; Creatine Kinase, Mitochondrial 1 (Ubiquitous); Acidic-Type Mitochondrial Creatine Kinase; Ubiquitous Mitochondrial Creatine Kinase; EC 2.7.3.2; Mia-CK; U-MtCK; CKMT1A; CKMT; CKMT1B; CKMT; Creatine kinase U-type; mitochondrial; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK

Background

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Anti-CKMT1A rAb Products

Creative Biolabs’ anti-CKMT1A recombinant antibodies have been engineered and validated for high specificity to exclusively detect the CKMT1A isoform without cross-reactivity against the sarcomeric (CKMT2) or cytosolic (CKM, CKB) isoforms. This level of isoform specificity is crucial to understand this tissue-specific energy metabolism enzyme in its proper context. Optimized for use in Western Blot on mitochondrial fractions as well as IHC, our rAbs are among the best research tools for studying metabolism and bioenergetics.

Table 1. Featured anti-CKMT1A recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs has an unwavering commitment to quality. Production of our anti-CKMT1A recombinant antibodies is supported by a rigorous quality assurance system to make sure each lot meets the Creative standard. This includes extensive testing for purity, isoform-specificity, and robust performance in our validated applications so you always have a high-quality reagent in hand.

Fig.1 WB analysis of anti-CKMT1A antibody (Cat# ZG-0497F, Creative Biolabs).

Customer Reviews

rAb Production

To help drive innovation and discovery in metabolism and bioenergetics research, Creative Biolabs takes advantage of leading-edge recombinant antibody production technologies. Our anti-CKMT1A recombinant antibodies are carefully engineered, validated, and screened to deliver high-affinity and isoform-specific detection of this key bioenergetics enzyme in even the most challenging applications.

Featured Anti-CKMT1A Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CKMT1A recombinant antibody production.

Fig.3 Gram-scale anti-CKMT1A recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to serving the research community with state-of-the-art tools to meet your needs. Our anti-CKMT1A antibodies are offered in a range of modalities to support a broad range of experimental workflows, making it easy for researchers all over the world to study this important enzyme.

Fig.4 Full-length anti-CKMT1A recombinant antibody production and modalities.

Accelerate your cell biology and metabolism research with Creative Biolabs’ premium anti-CKMT1A recombinant antibodies. Our portfolio is characterized by the highest isoform-specificity and the most thorough validation in our field to make the ideal tools for your most sensitive applications. Rely on our team of experts to deliver on your most critical projects. Contact our specialists today.