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CLEC6A
Anti-CLEC6A Recombinant Antibody Products
- Mouse Anti-CLEC6A Recombinant Antibody (NEUT-473CQ) (NEUT-473CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, Neut
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (monocytes)
Immune cell specificity
Group enriched (classical monocyte, myeloid DC)
Cell line specificity
Cell line enriched (NTERA-2)
Interaction
Associated with FCER1G (By similarity). Heterodimer with CLEC4D; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection (PubMed:23911656).
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