Anti-CLPP Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a pioneer in mitochondrial biology and rare disease research. This translates to the production of the highest quality anti-CLPP recombinant antibodies for your research. CLPP is a master regulator of mitochondrial protein quality control and the proteolytic subunit of the essential mitochondrial ClpXP protease. Our high-quality anti-CLPP antibodies are essential tools for research into mitochondrial homeostasis, Perrault syndrome, and the mitochondrial unfolded protein response (UPRmt).

CLPP: The Proteolytic Engine of Mitochondrial Protein Quality Control

Caseinolytic peptidase P (CLPP) is the catalytic core of a family of proteases. In the mitochondrial matrix, it assembles with other subunits to form a barrel-shaped complex that non-covalently binds with the ATPase chaperone ClpX. The resulting ClpXP protease complex degrades misfolded, damaged, or redundant proteins in the mitochondria in a process that is critical for protein homeostasis (proteostasis). ClpXP is also the central initiator of the mitochondrial unfolded protein response (UPRmt) stress signaling pathway. Loss-of-function mutations in CLPP lead to Perrault syndrome, a rare genetic disorder characterized by hearing loss and ovarian dysfunction.

Alternative Names

DFNB81; PRLTS3

Background

The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.

Anti-CLPP rAb Products

Creative Biolabs' anti-CLPP recombinant antibodies are engineered for high specificity and sensitivity to enable consistent detection of this crucial mitochondrial protease. They are thoroughly validated for critical applications such as Western Blot to measure protein levels in patient cells and IHC to study its distribution in tissues. Our rAbs provide the specificity that is required to enable mitochondrial research.

Table 1. Featured anti-CLPP recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is passionately committed to supporting rare disease and mitochondrial biology research. That is why every lot of anti-CLPP recombinant antibody goes through our full suite of validation tests for purity, binding, and consistent performance. This means you can rely on receiving a dependable, high-quality reagent that meets the exacting standards of your research.

Fig.1 WB analysis of anti-CLPP antibody (Cat# VS3-FY395, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is committed to facilitating advances in mitochondrial biology. To do this, we leverage our advanced production platforms. Our anti-CLPP recombinant antibodies are expressed in an optimized system to ensure that they recognize the native enzyme. This results in a product with high biological relevance and activity that will meet the needs of your research.

Featured Anti-CLPP Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CLPP recombinant antibody production.

Fig.3 Gram-scale anti-CLPP recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about empowering the research community with flexible and innovative tools to help you do your best work. Our anti-CLPP recombinant antibodies are available in a range of customizable formats so that you have everything you need to help researchers worldwide develop and test new therapeutic strategies for mitochondrial diseases.

Fig.4 Full-length anti-CLPP recombinant antibody production and modalities.

Accelerate your study of mitochondrial proteostasis with Creative Biolabs' superior anti-CLPP recombinant antibodies. Defined by our high specificity, rigorous validation, and exceptional consistency, our portfolio offers the ideal tools to power therapeutic development and diagnostics. Contact our specialists today to find out how we can support your critical research.