Anti-COMP Products

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For Research Use Only. Not For Clinical Use.

Musculoskeletal research depends on top-quality reagents like Creative Biolabs’ anti-COMP recombinant antibodies. Cartilage Oligomeric Matrix Protein (COMP) is an essential structural protein in the extracellular matrix (ECM) of cartilage and bone tissue. Our antibodies are essential tools for understanding the pathogenesis of skeletal dysplasias and osteoarthritis, and for examining the promise of COMP as a biomarker for joint disorders.

COMP: A Structural Hub in Cartilage and Bone

Cartilage oligomeric matrix protein (COMP) is a large (240 kDa) pentameric glycoprotein that is a major non-collagenous component of the ECM in cartilage, tendon and bone. COMP is involved in important structural and regulatory functions within these tissues. In a structural role, COMP associates with other ECM proteins including collagens and fibronectin to help organize and stabilize the ECM. COMP can also bind to a variety of growth factors and regulate their activity. Mutations in the COMP gene are responsible for two types of skeletal dysplasia, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Alternative Names

COMP; Cartilage Oligomeric Matrix Protein(Pseudoachondroplasia, Epiphyseal Dysplasia 1, Multiple); TSP5; Pseudoachondroplasia (Epiphyseal Dysplasia 1, Multiple); Thrombospondin-5; THBS5; Cartilage Oligomeric Matrix Protein (Pseudoachondroplasia, Epiphysea

Background

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Anti-COMP rAb Products

Creative Biolabs’ anti-COMP recombinant antibodies are highly specific and robust. Thoroughly validated to accurately detect COMP in tissue sections and biological fluids, our rAbs are optimized for use in applications such as IHC to localize COMP in cartilage, as well as ELISA to quantify COMP as a biomarker of cartilage turnover. Rely on Creative Biolabs’ rAbs to deliver the performance you need for high-quality rheumatology research.

Table 1. Featured anti-COMP recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs’ advanced production technologies are designed to support your most innovative research. Our anti-COMP recombinant antibodies are expressed in state-of-the-art systems that are optimized to ensure the antibodies recognize the native, multimeric form of COMP, so that you can trust you will receive a specific and active research tool for your experiments.

Featured Anti-COMP Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-COMP recombinant antibody production.

Fig.2 Gram-scale anti-COMP recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to helping you make your next scientific discovery. That is why we are pleased to offer your research a variety of flexible antibody modalities, including customizing your anti-COMP recombinant antibodies in a variety of formats such as matched pairs for ELISA.

Fig.3 Full-length anti-COMP recombinant antibody production and modalities.

Explore the critical functions of COMP in skeletal health with the unrivaled quality of Creative Biolabs’ recombinant antibodies. Our selection is unmatched in specificity and thorough validation to provide you with the best reagents for your arthritis and skeletal dysplasia research. Choose Creative Biolabs for quality you can depend on. Contact our experts today.