Anti-CSNK1E Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs understands the importance of Casein Kinase 1 Epsilon (CSNK1E) in neuroscience research. CSNK1E is a master regulator of the molecular clock that coordinates circadian rhythms, and antibodies to this important protein kinase are in demand for research into sleep and mood disorders, and for the discovery of new chronotherapeutic drugs. Creative Biolabs offers premium anti-CSNK1E recombinant antibodies for your neuroscience and chronobiology research.

CSNK1E: A Master Regulator of the Circadian Clock

Casein Kinase 1 Epsilon (CSNK1E) is a serine/threonine protein kinase that is a part of the central negative feedback loop of the molecular circadian clock. It phosphorylates the PERIOD (PER) and CRYPTOCHROME (CRY) proteins, the core negative regulators of the clock, in the nucleus of the cell. This marks PER and CRY for degradation by the ubiquitin-proteasome system, which is one of the most important steps for timing the ~24-hour cycle of circadian gene expression. Mutations that enhance or reduce CSNK1E activity cause inherited human disorders of sleep timing, and altered CSNK1E expression has been implicated in depression and bipolar disorder.

Alternative Names

Casein Kinase 1, Epsilon; CKI-Epsilon; EC 2.7.11.1; CKIe; CKIepsilon; EC 2.7.11; HCKIE

Background

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.

Anti-CSNK1E rAb Products

Creative Biolabs’ anti-CSNK1E recombinant antibodies are engineered for high specificity and validated to detect the epsilon isoform without cross-reactivity to the other highly homologous members of the CSNK1 family (delta, etc.). Optimized for Western Blot, immunoprecipitation to pull down and study the clock complex, and IHC, our recombinant antibodies are built to support the needs of high-quality neuroscience research with total confidence in your reagents.

Table 1. Featured anti-CSNK1E recombinant antibody products at Creative Biolabs.

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rAb Production

Creative Biolabs leverages the latest in recombinant antibody production technology to support the most advanced neuroscience research. Creative Biolabs’ anti-CSNK1E recombinant antibodies are expressed in optimized systems to ensure the reagent recognizes the native form of the enzyme with high specificity and maximum activity.

Featured Anti-CSNK1E Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CSNK1E recombinant antibody production.

Fig.2 Gram-scale anti-CSNK1E recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to offering the most innovative and flexible solutions to enable research. Creative Biolabs’ anti-CSNK1E recombinant antibodies are available in customizable formats to meet your experimental needs, providing researchers around the world with the tools to study this important enzyme.

Fig.3 Full-length anti-CSNK1E recombinant antibody production and modalities.

Decode CSNK1E’s role in circadian biology with Creative Biolabs’ recombinant antibodies. Built on a foundation of rigorous validation and exceptional performance, our portfolio offers the ideal tools to support your chronobiology and CNS drug discovery programs. Don’t wait, trust the experts at Creative Biolabs to help you reach your next discovery. Talk to one of our specialists today.