Anti-CSNK2A1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers premium anti-CSNK2A1 recombinant antibodies for your cancer biology studies. The CSNK2A1 protein is the principal alpha catalytic subunit of the pro-oncogenic kinase CK2 and is a master regulator of cell growth, proliferation and survival. Our superior quality and specific antibodies are powerful tools to study its role in tumorigenesis and to develop novel cancer targeted therapies.

CSNK2A1: The Alpha Catalytic Subunit of the "Master Kinase" CK2

CSNK2A1 (Casein Kinase 2 Alpha 1) is the major catalytic subunit of Casein Kinase 2 (CK2). CK2 is a constitutively active, highly abundant, serine/threonine protein kinase complex and is required for cell viability. CK2 is a tetramer consisting of two catalytic subunits (alpha or alpha-prime) and two regulatory beta subunits. CK2 has one of the largest substrate specificities of any protein kinase, phosphorylating hundreds of proteins that are involved in almost every aspect of cell biology, including transcription, DNA repair, and signaling. CK2 is overexpressed in nearly all human cancers and functions to drive cell proliferation and inhibit apoptosis. Due to its central role in oncogenesis, CK2 has been referred to as a “master kinase”.

Alternative Names

Casein kinase II subunit alpha; CK II alpha; EC 2.7.11.1; CSNK2A1; CK2A1

Background

CSNK2A1 (Casein Kinase 2 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK2A1 include Okur-Chung Neurodevelopmental Syndrome and Cardiomyopathy, Dilated, 1P. Among its related pathways are Mitotic Prometaphase and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A3.

Anti-CSNK2A1 rAb Products

Creative Biolabs’ anti-CSNK2A1 recombinant antibodies have been engineered for the highest specificity and have been extensively validated to specifically detect the alpha subunit, without cross-reactivity to the alpha-prime (CSNK2A2) isoform, to help you study the unique contributions of the CK2 complex. Optimized for use in Western Blot, IHC, and immunoprecipitation, our rAbs provide high-quality and reproducible results.

Table 1. Featured anti-CSNK2A1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, our work is characterized by an unwavering commitment to quality. The production of our anti-CSNK2A1 recombinant antibodies is supported by a rigorous quality assurance program. Each lot is tested for purity, isoform specificity and performance to ensure that you get a reagent you can trust to produce high integrity data.

Fig.1 WB analysis of anti-CSNK2A1 antibody
(Cat# ZG-0092U, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is proud to support your innovative cancer research with advanced production technologies. Our anti-CSNK2A1 recombinant antibodies are expressed in optimized systems that ensure they will correctly recognize the native form of the enzyme to provide you a highly specific and active research tool.

Featured Anti-CSNK2A1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CSNK2A1 recombinant antibody production.

Fig.3 Gram-scale anti-CSNK2A1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing our customers with innovative and customizable solutions to help you study your targets. Our anti-CSNK2A1 recombinant antibodies are available in multiple customizable modalities to fit your experimental needs and to help researchers around the world study this important oncogenic kinase.

Fig.4 Full-length anti-CSNK2A1 recombinant antibody production and modalities.

Uncover the distinct functions of CK2 in cancer with Creative Biolabs’ high-quality anti-CSNK2A1 recombinant antibodies. Our library is characterized by stringent validation and unparalleled performance, making our products the ideal tools to support your cancer drug discovery efforts. Let our team of experts help you advance your next discovery. Contact us today.