Rabbit Anti-CSNK2A1 Recombinant Antibody (clone R05-7F8) (CAT#: VS3-FY1990)
This is a rabbit recombinant monoclonal antibody that is involved in the recognition of human CSNK2A1. It cross-reacts with mouse, rat. This R05-7F8 antibody is validated for western blot analysis of CSNK2A1 in Hela, CHO-K1, C6, mouse brain, Ramos lysates.
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WB
Figure 1 Anti-CSNK2A1 Antibody (VS3-FY1990) in WB.
The CSNK2A1 expression in Hela, CHO-K1, C6, mouse Brain, Ramos lysates were detected using the anti-CSNK2A1 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human CSNK2A1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CSNK2A1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-7F8
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 45 kDa, while the observed molecular weight stands at 45 kDa.
- Related Disease
- Okur-Chung Neurodevelopmental Syndrome and Cardiomyopathy, Dilated, 1P
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Casein Kinase 2 Alpha 1; Casein Kinase 2, Alpha 1 Polypeptide; EC 2.7.11.1; CK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase II Alpha 1 Subunit; Casein Kinase II Subunit Alpha; CK2 Catalytic Subunit Alpha; Protein Kinase CK2
- Gene ID
- 1457
- UniProt ID
- P68400
- Sequence Similarities
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase.
Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.
(P68400-CSK21_HUMAN)
Ubiquitination at Lys229 (NX_P68400 [NX_P68400-1])
Modification sites at PhosphoSitePlus (P68400)
Glycosylation from GlyGen (P68400) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- NP_001349699.1; NP_001349700.1; NP_001886.1; NP_808227.1; NP_808228.1
- Function
- Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.
May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response.
During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage.
Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1655z | Mouse Anti-CSNK2A1 Recombinant Antibody (clone 28C3) | WB, ELISA, IHC, IP | Mouse IgG2a, κ |
| MOB-2247MZ | Recombinant Mouse Anti-Human CSNK2A1 Antibody (clone 4H2) | ELISA, WB | Mouse antibody |
| ZG-0092U | Rabbit Anti-CSNK2A1 Recombinant Antibody (clone 2B6) | ELISA, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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