Anti-CTPS1 Products

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For Research Use Only. Not For Clinical Use.

Immuno-oncology and hematology researchers are able to explore the roles of CTPS1 in nucleotide metabolism with Creative Biolabs' recombinant antibodies. CTP Synthase 1 (CTPS1) is the enzyme responsible for the production of CTP in the pyrimidine synthesis pathway and is a known driver of immune cell proliferation. Creative Biolabs' anti-CTPS1 recombinant antibodies will help in your pursuit of understanding and targeted therapy development in cancer.

CTPS1: The Key Enzyme in Pyrimidine Synthesis

CTP Synthase 1 (CTPS1) is an enzyme involved in nucleotide metabolism that facilitates the formation of cytosine triphosphate (CTP) from UTP in the pyrimidine synthesis pathway. In this process, CTPS1 utilizes glutamine as a nitrogen donor. CTP, one of the four nucleotides necessary for DNA and RNA synthesis, is also involved in phospholipid synthesis. CTPS1 is the primary isoform expressed in lymphocytes and rapidly dividing cancer cells and is thought to be crucial for T-cell proliferation and certain leukemias. CTPS1 activity is often found at filamentous cytoophidia, implicating it as having a non-metabolic role in regulating pyrimidine biosynthesis. This vital role in proliferation and pyrimidine synthesis makes CTPS1 an attractive target for anti-cancer and immunosuppressive drugs.

Alternative Names

CTP Synthase 1; UTP--Ammonia Ligase 1; CTP Synthetase 1; EC 6.3.4.2; CTPS; Cytidine 5-Prime Triphosphate Synthetase;

Background

CTPS1 (CTP Synthase 1) is a Protein Coding gene. Diseases associated with CTPS1 include Immunodeficiency 24 and Sleeping Sickness. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and CTP synthase activity. An important paralog of this gene is CTPS2.

Anti-CTPS1 rAb Products

Creative Biolabs' anti-CTPS1 recombinant antibodies are of the highest quality and are engineered to provide high specificity and strong performance. They are validated to specifically detect CTPS1 enzyme. Optimized for use in Western Blot for analysis of expression, IHC on tumor and immune tissue sections, and immunofluorescence for detection of this enzymes' unique cytoophidia formation, our rAbs offer the reliability and quality researchers need for their metabolic research.

Table 1. Featured anti-CTPS1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages modern and sophisticated antibody production platforms in order to meet the needs of this specialized research area. Our anti-CTPS1 recombinant antibodies are produced in carefully optimized systems so that the rAbs can accurately recognize the native form of this enzyme, and can be trusted as a highly specific and active research tool.

Featured Anti-CTPS1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CTPS1 recombinant antibody production.

Fig.2 Gram-scale anti-CTPS1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific discovery and meeting the needs of all researchers by providing antibody solutions in a variety of flexible modalities. Creative Biolabs' anti-CTPS1 recombinant antibodies are available in a number of customizable formats so that you can find the antibody modalities to best fit your experiments and research approaches for studying this important metabolic enzyme.

Fig.3 Full-length anti-CTPS1 recombinant antibody production and modalities.

Creative Biolabs offers recombinant antibodies that are the result of our commitment to rigorous validation and high specificity. This enables you to select the appropriate tools and effectively elucidate the roles of CTPS1 in nucleotide metabolism, cancer, and proliferation of immune cells. Experience quality that drives discovery with Creative Biolabs' recombinant antibodies. Contact our specialists today.