Anti-CTSS Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a global provider of recombinant antibodies for immunology and autoimmune disease research. CTSS is a critical protease of antigen presentation, master regulator of immune responses and a major therapeutic target. Creative Biolabs elite anti-CTSS recombinant antibodies are reliable tools for studying its function in autoimmunity, inflammation and cancer, as well as for developing innovative immunomodulatory therapeutics.

CTSS: The Master Protease of Antigen Presentation

Cathepsin S (CTSS), a lysosomal cysteine protease, is highly expressed by professional antigen-presenting cells (APCs) including dendritic cells, B-cells and macrophages. Its primary role is to cleave the invariant chain (Ii) which is non-covalently bound to newly synthesized MHC class II molecules. Cathepsin S removes the last piece of Ii called CLIP, thereby making the peptide-binding groove accessible for antigenic peptides to be loaded onto the MHC-II molecule for presentation to CD4+ T-helper cells. The loading of peptide antigens onto MHC-II molecules is the rate-limiting step in the activation of T-helper cells, so inhibition of Cathepsin S is a logical approach to suppress autoimmune responses.

Alternative Names

Cathepsin S

Background

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Cercarial Dermatitis and Mandibular Cancer. Among its related pathways are Bacterial infections in CF airways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.

Anti-CTSS rAb Products

Creative Biolabs' anti-CTSS recombinant antibodies are specifically engineered for maximal specificity and performance. Each antibody is extensively validated to specifically detect CTSS within APCs. Optimized for identifying CTSS-expressing cells by flow cytometry as well as Western Blot and IHC, our anti-CTSS rAbs are a premier reagent for immunology and drug discovery research.

Table 1. Featured anti-CTSS recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to quality in all phases of production. Manufacturing of our anti-CTSS recombinant antibodies is strictly controlled by an extensive quality assurance system. Each lot is rigorously tested for purity, specificity, and reproducible performance in relevant APC models so you can be confident that you are receiving the highest-quality reagent for your research.

Fig.1 IHC analysis of anti-CTSS antibody
(Cat# ZG-0626J, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is focused on driving forward scientific discovery by implementing leading-edge production technologies. Our anti-CTSS recombinant antibodies are meticulously designed and optimized to give the highest possible specificity and sensitivity for detecting this critical target.

Featured Anti-CTSS Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CTSS recombinant antibody production.

Fig.3 Gram-scale anti-CTSS recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to providing flexible and innovative tools to support the research community. Our anti-CTSS recombinant antibodies are available in a wide variety of modalities to support a diverse array of experimental approaches for studying this important protease.

Fig.4 Full-length anti-CTSS recombinant antibody production and modalities.

Move your immunology research forward with Creative Biolabs' superior anti-CTSS recombinant antibodies. Creative Biolabs' portfolio is defined by the highest specificity and rigorously validated performance so you can be sure you have the right tools for your drug discovery and basic research. You can count on us to have your back, so contact our experts today.