Afuco™ Anti-Human CTSS ADCC Recombinant Antibody (Fsn0503h), ADCC Enhanced (CAT#: AFC-186CL)
Anti-CTSS ADCC Enhanced Antibody (Fsn0503h) is an ADCC enhanced antibody produced by our Afuco™ platform. Fsn0503h is a fully human anti-Cathepsin S antibody with anti-tumour and anti-angiogenic properties. Cathepsin S is a cysteine protease highly expressed in many cancers including colorectal, breast, prostate and glioblastoma's. It is involved in tumour progression through extracellular matrix remodelling. Fusion Therapeutics has generated positive preclinical data demonstrating efficacy of Fsn0503h in multiple models both as a monotherapy and in combination with approved agents.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/if_selected.jpg
Figure 2 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/ihc_selected.jpg
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/460/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/460/ihc_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_8.jpg
Figure 5 Cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_B_8_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_B_8_5.jpg
Figure 6 Lung
(Alveolar cells type Alveolar cells type I Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_2_4.jpg
(Alveolar cells type Alveolar cells type I Macrophages Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_2_4.jpg
Figure 7 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_3.jpg
Figure 8 RNA cell line category: Cell line enhanced (CAPAN-2, HMC-1, U-698)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163131-CTSS
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163131-CTSS
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Colorectal Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1486CL | Mouse Anti-CTSS Recombinant Antibody (TAB-1486CL) | ELISA, WB, Inhib | Mouse IgG1 |
| TAB-1486CL-S(P) | Mouse Anti-CTSS Recombinant Antibody; scFv Fragment (TAB-1486CL-S(P)) | ELISA, WB, Inhib | Mouse scFv |
| TAB-1486CL-F(E) | Mouse Anti-CTSS Recombinant Antibody; Fab Fragment (TAB-1486CL-F(E)) | ELISA, WB, Inhib | Mouse Fab |
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