Afuco™ Anti-Human CTSS ADCC Recombinant Antibody (Fsn0503h), ADCC Enhanced
CAT#: AFC-186CL
Anti-CTSS ADCC Enhanced Antibody (Fsn0503h) is an ADCC enhanced antibody produced by our Afuco™ platform. Fsn0503h is a fully human anti-Cathepsin S antibody with anti-tumour and anti-angiogenic properties. Cathepsin S is a cysteine protease highly expressed in many cancers including colorectal, breast, prostate and glioblastoma's. It is involved in tumour progression through extracellular matrix remodelling. Fusion Therapeutics has generated positive preclinical data demonstrating efficacy of Fsn0503h in multiple models both as a monotherapy and in combination with approved agents.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/460/ihc_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_B_8_5.jpg
Normal Tissue
Figure 6 Lung
Alveolar cells type Alveolar cells type I Macrophages Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_2_4.jpg
Normal Tissue
Figure 7 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2988/8252_A_8_3.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CAPAN-2, HMC-1, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163131-CTSS
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Colorectal Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CTSS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1486CL | Mouse Anti-CTSS Recombinant Antibody (TAB-1486CL) | ELISA, WB, Inhib | Mouse IgG1 |
| TAB-1486CL-S(P) | Mouse Anti-CTSS Recombinant Antibody; scFv Fragment (TAB-1486CL-S(P)) | ELISA, WB, Inhib | Mouse scFv |
| TAB-1486CL-F(E) | Mouse Anti-CTSS Recombinant Antibody; Fab Fragment (TAB-1486CL-F(E)) | ELISA, WB, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0870 | Hi-Affi™ Rabbit Anti-CTSS Recombinant Antibody (clone DS870AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3368 | PE-DRB1*13:02/Human CTSS (DPTLDHHWHLWKKTYGKQYKE) MHC Tetramer | FCM | |
| MHC-LC3369 | PE-DRB1*13:02/Human CTSS (DPTLDHHWHLWKKTYGKQYK) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-016CN | Mouse Anti-CTSS Recombinant Antibody (NS-016CN) | ELISA, WB | Mouse IgG1, κ |
| NS-016CN-F(E) | Mouse Anti-CTSS Recombinant Antibody; Fab Fragment (NS-016CN-F(E)) | ELISA, WB | Mouse Fab |
| NS-016CN-S(P) | Mouse Anti-CTSS Recombinant Antibody; scFv Fragment (NS-016CN-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032LY | Mouse Anti-CTSS Recombinant Antibody (clone 1E11) | WB | Mouse IgG |
| ZG-0626J | Rabbit Anti-CTSS Recombinant Antibody (clone 9B10) | ELISA, IHC | Rabbit IgG |
| VS13-YC273 | Rabbit Anti-CTSS Recombinant Antibody (VS13-YC273) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032LY-S(P) | Mouse Anti-CTSS Recombinant Antibody (clone 1E11); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032LY-F(E) | Mouse Anti-CTSS Recombinant Antibody (clone 1E11); Fab Fragment | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1790 | Anti-CTSS Immunohistochemistry Kit | IHC | |
| VS-0525-XY1791 | Anti-Mouse CTSS Immunohistochemistry Kit | IHC |
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