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    CYBB

    AbPlus Recombinant Antibody Products Formats

    Anti-CYBB Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
    Protein class

    Disease related genes, Human disease related genes, Potential drug targets, Transporters

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Macrophages, Kupffer cells, monocytes, Hofbauer cells)

    Immune cell specificity

    Immune cell enhanced (classical monocyte, intermediate monocyte)

    Cell line specificity

    Group enriched (Daudi, NB-4, REH, RPMI-8226)

    Interaction

    Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex (PubMed:19028840, PubMed:3600769, PubMed:9224653). Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer (PubMed:28351984). Interacts with NCF2; the interaction is enhanced in the presence of GBP7 (By similarity). The CYBA-CYBB complex interacts with GBP7 (By similarity).

    Molecular function

    Ion channel, Oxidoreductase, Voltage-gated channel

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