Anti-CYP19A1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a world-renowned provider of endocrinology and oncology research tools with a reputation for excellence in anti-CYP19A1 (Aromatase) recombinant antibodies. Aromatase is the rate-limiting enzyme for the synthesis of estrogens, a widely-accepted therapeutic target for hormone dependent breast cancer. The recombinant antibodies in our portfolio are rigorously validated to be of high specificity and performance and can be used for research into steroidogenesis, endocrine pathologies, and mechanisms of action of Aromatase Inhibitors.

CYP19A1: The Gateway to Estrogen Synthesis

Aromatase, also known as P450arom or estrogen synthase, is a cytochrome P450 (CYP450) enzyme, encoded by the CYP19A1 gene. It is the only enzyme responsible for the aromatization of androgens, by converting androstenedione to estrone and testosterone to estradiol. This enzyme is responsible for the last step of estrogen biosynthesis in the body. While it is essential for a wide variety of both reproductive and non-reproductive physiological functions, tissue Aromatase activity in peripheral tissues is the main source of estrogen production in postmenopausal women and one of the driving forces for the proliferation of hormone receptor-positive breast cancer.

Alternative Names

CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked

Background

CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP19A1 include Aromatase Deficiency and Aromatase Excess Syndrome. Among its related pathways are Ovarian Infertility Genes and Androstenedione and testosterone biosynthesis and metabolism p.1. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.

Anti-CYP19A1 rAb Products

Creative Biolabs' anti-Aromatase recombinant antibodies are of the highest quality and exhibit high specificity and performance characteristics. All products are rigorously validated to be able to specifically detect Aromatase enzyme in adipose, gonadal, and tumor tissues. These antibodies are optimized for IHC and Western Blotting, so you can be confident of the specificity you need to understand estrogen production in the body and the efficacy of your experimental therapeutics.

Table 1. Featured anti-CYP19A1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs' standard of excellence is powered by robust quality control. We have a strong quality assurance team in place to ensure our anti-Aromatase recombinant antibodies are produced with attention to the highest levels of purity, specificity, and consistent performance. We know how important your research is, and we will ensure that the reagent you receive is capable of giving you reliable, reproducible results.

Customer Reviews

rAb Production

In order to contribute to the very important fields of oncology and endocrinology, Creative Biolabs' recombinant antibody production technologies are state of the art. Our anti-Aromatase recombinant antibodies are generated in optimized systems to express antibodies that can accurately recognize this membrane-associated P450 enzyme. The antibodies are highly specific and active tools for your research.

Featured Anti-CYP19A1 Recombinant Antibody Production Platforms
Fig.4 Milligram-scale anti-CYP19A1 recombinant antibody production.

Fig.5 Gram-scale anti-CYP19A1 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about enabling endocrine research and have made it our mission to provide scientists around the world with flexible antibody solutions. Our recombinant anti-Aromatase antibodies can be produced in a variety of customizable formats to fit your research needs and to help you investigate this important enzyme to find next-generation therapeutics.

Fig.6 Full-length anti-CYP19A1 recombinant antibody production and modalities.

Research the role of Aromatase in physiology and disease with the high quality recombinant antibodies from Creative Biolabs. Known for their high specificity and excellent validation, our portfolio will provide you with the perfect tool for your cancer and endocrinology research. Don't hesitate to reach out and trust our science team to provide you with a strong foundation for your research.