Anti-Casp4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your one-stop shop for innate immunity research! These high-specificity anti-CASP4 recombinant antibodies will allow you to interrogate one of the principal sensors of intracellular bacteria. Caspase-4 (CASP4) is a human inflammatory caspase that directly recognizes intracellular pathogens, and is a well-known initiator of a non-canonical inflammasome pathway. Our high-quality antibodies are the tools you need for your research on host-pathogen interactions, sepsis, and pyroptotic cell death.

CASP4: A Direct Sensor of Intracellular Bacteria

Caspase-4 (CASP4) and its close homolog Caspase-5 are human inflammatory caspases. Their murine ortholog is Caspase-11. Unlike the canonical NLRP3 inflammasomes that require expression of separate sensor proteins, Caspase-4 is able to directly recognize intracellular lipopolysaccharide (LPS) (the component of gram-negative bacterial outer membrane) when it is present in the cytosol of the host cell, and act as its own sensor protein. This direct recognition results in oligomerization and activation of caspase-4, which then cleaves Gasdermin D, resulting in pyroptosis, and also activates the NLRP3 inflammasome, promoting IL-1beta production. This critical anti-intracellular bacterial defense pathway is also a central driver of septic shock.

Alternative Names

CASP4; caspase 4, apoptosis-related cysteine peptidase; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease;

Background

This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described.

Anti-CASP4 rAb Products

Our anti-CASP4 recombinant antibodies are designed to be of the highest specificity and quality. These antibodies are validated to recognize both the pro-form and active forms of caspase-4, and optimized for Western Blot to follow the activation of the non-canonical inflammasome. They are a high-quality antibody solution that will become the gold standard for your innate immunity research.

Table 1. Featured anti-CASP4 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has an established platform to support research in the complex field of immunology. Our anti-CASP4 recombinant antibodies are expressed in an optimized system for accurate recognition of the different forms of the enzyme, so you get a highly specific, active antibody for your experiments.

Featured Anti-CASP4 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CASP4 recombinant antibody production.

Fig.2 Gram-scale anti-CASP4 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting scientific discovery. Our recombinant antibodies, including our anti-CASP4 recombinant antibodies, are available in a variety of modalities to meet the needs of a wide range of experimental applications. Get the tools you need to study this key inflammatory pathway from Creative Biolabs. We work with researchers around the world to enable study of their chosen targets.

Fig.3 Full-length anti-CASP4 recombinant antibody production and modalities.

Study the activation of the non-canonical inflammasome pathway with our validated and consistent anti-CASP4 recombinant antibodies. Creative Biolabs' portfolio of reagents have the rigorous testing and validation you need to study this important sensor of intracellular bacteria in sepsis and infectious disease. Contact our scientific team to learn more.