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DEF6
Anti-DEF6 Recombinant Antibody Products
- Recombinant Mouse Anti-Human DEF6 Antibody (MOB-1084MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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- Mouse Anti-NHP DEF6 Recombinant Antibody (clone OTI1E3) (VS-1024-XY160)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF
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- Anti-DEF6 Immunohistochemistry Kit (VS-0325-XY650)
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- Species Reactivity: Human, Rat
- Target: DEF6
- Application: IHC
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For Research Use Only. Not For Clinical Use.
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Hofbauer cells, NK-cells, T-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (JURKAT, MOLT-4, NB-4, REH, THP-1, U-937)
Interaction
Interacts with ZAP70 (By similarity). Interacts with IRF4, activated RAC1 and F-actin. Both the phosphorylated and non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3).
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