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DNM1L
Loading...Anti-DNM1L Products
- Mouse Anti-DNM1L Recombinant Antibody (VS3-FY2690) (VS3-FY2690)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, ICC, FC, ELISA
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- Mouse Anti-NHP DNM1L Recombinant Antibody (clone OTI4F6) (VS-1024-XY170)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IHC, IF
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- Anti-DNM1L Immunohistochemistry Kit (VS-0525-XY2043)
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- Species Reactivity: Human
- Target: DNM1L
- Application: IHC
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- Anti-Mouse DNM1L Immunohistochemistry Kit (VS-0525-XY2044)
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- Species Reactivity: Human, Rat, Mouse, Bovine, Chicken, Hamster
- Target: DNM1L
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Oligomerizes in a GTP-dependent manner to form membrane-associated tubules with a spiral pattern. Interacts with GSK3B and MARCHF5. Interacts (via the GTPase and B domains) with UBE2I; the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PPP3CA; the interaction dephosphorylates DNM1L and regulates its transition to mitochondria. Interacts with BCL2L1 isoform BCL-X(L) and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with MFF; the interaction is inhinited by C11orf65/MFI. Interacts with FIS1. Interacts with MIEF2 and MIEF1; GTP-dependent, regulates GTP hydrolysis and DNM1L oligomerization. Interacts with PGAM5; this interaction leads to dephosphorylation at Ser-656 and activation of GTPase activity and eventually to mitochondria fragmentation. Interacts with RALBP1; during mitosis, recruits DNM1L to the mitochondrion and mediates its activation by the mitotic kinase cyclin B-CDK1 (PubMed:21822277).
Molecular function
Hydrolase
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