Mouse Anti-DNM1L Recombinant Antibody (VS3-FY2690) (CAT#: VS3-FY2690)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Dynamin 1 like of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ICC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 81.9 kDa.

• Related Disease
• Alzheimer's disease

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Dynamin 1 Like; Dynamin Family Member Proline-Rich Carboxyl-Terminal Domain Less; Dynamin-Related Protein 1; Dnm1p/Vps1p-Like Protein; Dynamin-Like Protein IV; Dynamin-Like Protein 4; EC 3.6.5.5; DYMPLE; HDYNIV

• Gene ID
• 10059

• Sequence Similarities
• Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

• Cellular Localization
• Cytoplasm, cytosol
  Golgi apparatus
  Endomembrane system; Peripheral membrane protein
  Mitochondrion outer membrane; Peripheral membrane protein
  Peroxisome
  Membrane, clathrin-coated pit

• Post Translation Modifications
• Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission
  Sumoylated on various lysine residues within the B domain, probably by MUL1.
  S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage.
  Ubiquitination by MARCHF5 affects mitochondrial morphology.
  O-GlcNAcylation augments the level of the GTP-bound active form of DNM1L and induces translocation from the cytoplasm to mitochondria in cardiomyocytes.
  Glycosylation at Thr585 and Thr586
  Ubiquitination at Lys238
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 4 sites, 1 O-linked glycan (2 sites)

• Protein Refseq
• XP_011518845.1; XP_047284003.1; XP_054226690.1; XP_054226691.1; NP_001265392.1

• Function
• Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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