Mouse Anti-DNM1L Recombinant Antibody (VS3-FY2690)
CAT#: VS3-FY2690
This anti-DNM1L antibody is a mouse recombinant monoclonal antibody that is created to attach to DNM1L. The calculated molecular weight of the antigen is 81.9 kDa. It shows capability of cross-reacting with human, mouse and rat. This monoclonal antibody is potential for conducting research on Alzheimer's disease. This monoclonal antibody can be used in Western Blot, Immunocytochemistry, Flow cytometry, ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9952/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/94452_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/94452_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/94452_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/94452_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39324/94452_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087470-DNM1L
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Dynamin 1 like of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 81.9 kDa.
- Related Disease
- Alzheimer's disease
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- Dynamin 1 Like; Dynamin Family Member Proline-Rich Carboxyl-Terminal Domain Less; Dynamin-Related Protein 1; Dnm1p/Vps1p-Like Protein; Dynamin-Like Protein IV; Dynamin-Like Protein 4; EC 3.6.5.5; DYMPLE; HDYNIV
- Gene ID
- 10059
- Sequence Similarities
- Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
- Cellular Localization
- Cytoplasm, cytosol
Golgi apparatus
Endomembrane system; Peripheral membrane protein
Mitochondrion outer membrane; Peripheral membrane protein
Peroxisome
Membrane, clathrin-coated pit
- Post Translation Modifications
- Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission
Sumoylated on various lysine residues within the B domain, probably by MUL1.
S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage.
Ubiquitination by MARCHF5 affects mitochondrial morphology.
O-GlcNAcylation augments the level of the GTP-bound active form of DNM1L and induces translocation from the cytoplasm to mitochondria in cardiomyocytes.
Glycosylation at Thr585 and Thr586
Ubiquitination at Lys238
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_011518845.1; XP_047284003.1; XP_054226690.1; XP_054226691.1; NP_001265392.1
- Function
- Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "DNM1L"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0560CT | Recombinant Mouse anti-Human DNM1L Monoclonal antibody (EML1146) | FC, IHC-P, WB | |
| VS3-XY588 | Mouse Anti-DNM1L Recombinant Antibody (clone 10D2) | ELISA, WB, ICC, FC | Mouse IgG1 |
| VS3-XY589 | Mouse Anti-DNM1L Recombinant Antibody (clone 4E11B11) | ELISA, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY170 | Mouse Anti-NHP DNM1L Recombinant Antibody (clone OTI4F6) | WB, IHC, IF | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2043 | Anti-DNM1L Immunohistochemistry Kit | IHC | |
| VS-0525-XY2044 | Anti-Mouse DNM1L Immunohistochemistry Kit | IHC |
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