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EIF2AK3
Loading...Anti-EIF2AK3 Products
- Mouse Anti-EIF2AK3 Recombinant Antibody (VS3-WK1179) (VS3-WK1179)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
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- Chicken Anti-PERK Polyclonal IgY (BRD-0756MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ELISA, IHC, IP, WB
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- Anti-EIF2AK3 Immunohistochemistry Kit (VS-0525-XY2206)
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- Species Reactivity: Human
- Target: EIF2AK3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Plasma cells)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Cell line enhanced (Daudi, U-266/70, U-698)
Interaction
Forms dimers with HSPA5/BIP in resting cells (By similarity). Oligomerizes in ER-stressed cells (By similarity). Interacts with DNAJC3 and MFN2 (By similarity). Interacts with TMEM33 (PubMed:26268696). Interacts with PDIA6 (PubMed:24508390). Interacts with LACC1 (PubMed:31875558).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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