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ELAVL1
Anti-ELAVL1 Recombinant Antibody Products
- Recombinant Mouse Anti-Human ELAVL1 Antibody (MOB-1825MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- PE-B*07:02/Human ELAVL1 (NPNQNKNVAL) MHC Tetramer (MHC-LC2088)
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- Class: Class I
- Antigen: ELAVL1
- Antigen Species: Human
- Peptide: NPNQNKNVAL
- Conjugate: PE
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- APC-B*07:02/Human ELAVL1 (NPNQNKNVAL) MHC Tetramer (MHC-LC2089)
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- Class: Class I
- Antigen: ELAVL1
- Antigen Species: Human
- Peptide: NPNQNKNVAL
- Conjugate: APC
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- Rabbit Anti-ELAVL1 Recombinant Antibody (clone JM96-33) (MRO-0803-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer and homodimer (in vitro) (PubMed:17632515, PubMed:20219472). Interacts with ANP32A (PubMed:11729309). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with IGF2BP1; the interaction is enhanced by SEPIN14P20 peptide RBPR (PubMed:32245947, PubMed:29476152). Interacts with IGF2BP2 and IGF2BP3 (PubMed:23640942, PubMed:29476152). Interacts with HNRNPL (PubMed:18161049). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ILF3; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with PLEKHN1 (PubMed:18191643, PubMed:27616329). Interacts with SHFL; the interaction increases in presence of RNA (PubMed:27974568). Interacts with YBX1; interaction recruits ELAVL1 on C5-methylcytosine (m5C)-containing mRNAs, thereby promoting mRNA stability (PubMed:31358969).
Molecular function
RNA-binding
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