Rabbit Anti-ELAVL1 Recombinant Antibody (clone R04-3A6)

CAT#: VS3-XY3343

This antibody is a recombinant rabbit antibody binding with ELAVL1 (ELAV like RNA binding protein 1), which involves in embryonic stem cell (ESC) differentiation. It reacts with human, mouse and rat ELAVL1. It has been detected using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 IHC staining of human parathyroid gland Figure 3 Cerebral cortex Figure 4 Colon Figure 5 Kidney Figure 6 Testis Figure 7 RNA cell line category: Low cell line specificity

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat ELAVL1
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R04-3A6
  • Related Disease
  • Colorectal Cancer; Ureteral Obstruction

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IHC: 1/50-1/100
    IF: 1/50-1/200
    IP: 1/20
    FC: 1/50-1/100

Target

  • Alternative Names
  • HUR; Hua; MelG; ELAV1
  • Long Name
  • ELAV like RNA binding protein 1
  • Cellular Localization
  • Nucleus, Cytoplasm, Stress granule
  • Post Translation Modifications
  • Phosphorylated by MAPKAPK2 (PubMed:14517288).
    Phosphorylated by PRKCD (PubMed:18285462).
    (Q15717-ELAV1_HUMAN)
    Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. (Q15717-ELAV1_HUMAN)
    Ubiquitination at Lys50, Lys55, Lys72, Lys104, Lys120, Lys191, Lys313, and Lys320 (NX_Q15717 [NX_Q15717-1])
    Modification sites at PhosphoSitePlus (Q15717)
    Glycosylation from GlyGen (Q15717) 1 site, 1 O-linked glycan (1 site)
  • Function
  • RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, 18285462, 31358969).
    Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation.
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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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Protocol & Troubleshooting

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Isotype Control

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Secondary Antibody

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