ENPP1

ENPP1 encodes an enzyme that plays a role in the regulation of cellular signaling through the hydrolysis of nucleotide pyrophosphates, such as ATP and other nucleotides. It is involved in the modulation of phosphate homeostasis, particularly in the bones and kidneys. ENPP1 is crucial for the regulation of mineralization, and mutations in this gene can lead to disorders such as generalized arterial calcification of infancy (GACI), a disease that causes abnormal calcification in blood vessels. The protein also participates in the regulation of insulin receptor signaling, influencing glucose metabolism.