Mouse Anti-ENPP1 scFv-Fc Chimera (VS-0625-FY10)
CAT#: VS-0625-FY10
Anti-ENPP1 scFv-FC is a recombinant fusion protein designed to specifically target Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1). ENPP1 is a transmembrane enzyme involved in regulating extracellular pyrophosphate levels, which are critical for bone mineralization and, notably, also implicated as an innate immune checkpoint in the cGAMP-STING pathway, especially in cancer. This product features a high-affinity single-chain variable fragment (scFv) that binds to ENPP1, fused to the Fc domain of a human immunoglobulin (e.g., IgG1). This design not only confers high specificity and stability but also enhances the protein's half-life and potentially allows for effector functions. Anti-ENPP1 scFv-FC is a valuable tool for research into bone disorders, metabolic diseases (like insulin resistance), and particularly for exploring novel immunotherapeutic strategies in cancer, aiming to modulate the STING pathway by blocking ENPP1 activity.
Specifications
- Immunogen
- The antibody to ENPP1 was raised against the human recombinant ENPP1 protein.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human ENPP1
- Species Reactivity
- Human, Mouse
- Applications
- Flow Cytometry, Inhibition
- Related Disease
- Bone disorders, metabolic diseases
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Ectonucleotide Pyrophosphatase/Phosphodiesterase 1; Phosphodiesterase I/Nucleotide Pyrophosphatase 1; Plasma-Cell Membrane Glycoprotein PC-1; E-NPP 1; PDNP1; M6S1; NPPS; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1; Membrane Component, Chromosome 6, Surface Marker 1; Membrane Component Chromosome 6 Surface Marker 1
- Gene ID
- 5167
- UniProt ID
- P22413
- Long Name
- Ectonucleotide Pyrophosphatase/Phosphodiesterase 1
- Sequence Similarities
- Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
Basolateral cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.
N-glycosylated.
The secreted form is produced through cleavage at Lys-103 by intracellular processing.
Glycosylation at Asn179, Asn285, Asn341, Asn477, Asn585, Asn643, Asn700, Asn731, and Asn748
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from Gly 11 sites, 44 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_006199.2
- Function
- Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity).
PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ENPP1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY105 | CytoStream™ Rat Anti-ENPP1 Recombinant Antibody (clone YE1/19.1) | FC | Rat IgG2b, kappa |
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