EPHA4

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

Intracellular, Membrane (different isoforms)

Cell type enriched (Excitatory neurons)

Group enriched (NK-cell, memory CD4 T-cell, memory CD8 T-cell, MAIT T-cell, gdT-cell, basophil, memory B-cell, T-reg, naive B-cell, naive CD4 T-cell)

Cell line enhanced (AF22, ASC diff, CACO-2, U-2197)

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation (By similarity). Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Forms a ternary complex composed of ADAM10, CADH1 and EPHA4; within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (By similarity).

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase