Human Anti-EPHA4 (clone 10C12) scFv-Fc Chimera (CAT#: VS-0325-FY80)
The anti-EPHA4 scFv-Fc antibody targets EPHA4, a receptor tyrosine kinase involved in axon guidance and neural development. It can modulate EPHA4 signaling pathways, making it a potential tool for studying neurobiology and related diseases. The scFv-Fc format enhances its stability and bioavailability, allowing for prolonged action in vivo. The 10C12 scFv-Fc expressed in P. pastoris has membrane anchoring properties, ensuring its effective antigen binding on the cell surface.
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Normal Tissue
Figure 1 Cerebral cortex
(Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_7_5.jpg
(Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_7_5.jpg
Figure 2 Cerebellum
(Molecular layer - neuropil
Staining:Medium
Intensity: Moderate
Molecular layer cells - cytoplasm/membrane
Staining:High
Intensity: Strong
Synaptic glomeruli - capsule
Staining:Medium
Intensity: Moderate
Synaptic glomeruli - core
Staining:Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_8_8.jpg
(Molecular layer - neuropil
Staining:Medium
Intensity: Moderate
Molecular layer cells - cytoplasm/membrane
Staining:High
Intensity: Strong
Synaptic glomeruli - capsule
Staining:Medium
Intensity: Moderate
Synaptic glomeruli - core
Staining:Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_8_8.jpg
Figure 3 Colon
(Enterocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_3.jpg
(Enterocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_3.jpg
Figure 4 Kidney
(Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_5.jpg
(Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_5.jpg
Figure 5 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_5_6.jpg
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_5_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, ASC diff, CACO-2, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116106-EPHA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116106-EPHA4
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EPHA4
- Species Reactivity
- Human
- Clone
- 10C12
- Applications
- Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- EPH Receptor A4; Tyrosine-Protein Kinase Receptor SEK; Tyrosine-Protein Kinase TYRO1; EPH-Like Kinase 8; EC 2.7.10.1; TYRO1; HEK8; EK8
- Gene ID
- 2043
- UniProt ID
- P54764
- Long Name
- EPH Receptor A4
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Cellular Localization
- Cell membrane; Cell projection, axon; Cell projection, dendrite; Postsynaptic density membrane; Early endosome; Cell junction, adherens junction
- Post Translation Modifications
- Glycosylation at Asn235, Asn340, Asn408, and Asn545
Ubiquitination at Lys735
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001291465.1; NP_001291466.1; NP_001350677.1; NP_004429.1
- Function
- EPHA4 (Eph receptor A4) is a receptor tyrosine kinase involved in various developmental processes, including axon guidance, cell migration, and tissue boundary formation. It plays a significant role in neuronal development and is implicated in diseases such as cancer and neurological disorders.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-386MZ | Anti-Human EPHA4 Recombinant Antibody (65) | Cyt | Human antibody |
| TAB-387MZ | Anti-Human EPHA4 Recombinant Antibody (336) | Cyt | Human antibody |
| TAB-386MZ-S(P) | Anti-Human EPHA4 Recombinant Antibody scFv Fragment (65) | FC | Human antibody |
| TAB-386MZ-F(E) | Anti-Human EPHA4 Recombinant Antibody Fab Fragment (65) | FC | Human antibody |
| TAB-387MZ-F(E) | Anti-Human EPHA4 Recombinant Antibody Fab Fragment (336) | FC | Human antibody |
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