Anti-EPHX2 Products

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For Research Use Only. Not For Clinical Use.

Anti-EPHX2 recombinant antibodies. Accelerate your cardiovascular and inflammation research with ultra-specific anti-EPHX2 recombinant antibodies from Creative Biolabs. EPHX2, the soluble epoxide hydrolase enzyme, is a vital regulator of vasoactive lipid mediators. Our top-tier antibodies are the perfect tools to study hypertension, inflammation, and pain or develop novel therapeutics targeting this enzyme.

EPHX2: The Soluble Epoxide Hydrolase in Cardiovascular Regulation

The cytosolic enzyme Epoxide Hydrolase 2 (EPHX2), also known as soluble epoxide hydrolase (sEH), is a metabolizing enzyme that terminates the actions of epoxyeicosatrienoic acids (EETs). EETs are anti-inflammatory and vasodilatory lipid signaling molecules that are derived from arachidonic acid. By converting these cytoprotective EETs to their inactive diol forms, sEH has opposing effects to EETs. Inhibiting sEH increases tissue EET levels, leading to lower blood pressure, decreased inflammation, and diminished pain. In fact, sEH is a major therapeutic target for cardiovascular and inflammatory disorders.

Alternative Names

Epoxide Hydrolase 2; Epoxide Hydrolase 2, Cytoplasmic; Epoxide Hydrolase 2, Cytosolic; Epoxide Hydrolase, Soluble; Epoxide Hydratase; CEH; SEH

Background

This gene encodes a member of the epoxide hydrolase family. The protein is predominantly located in the cytosol and peroxisomes. It has been shown to bind to specific epoxides and convert them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.

Anti-EPHX2 rAb Products

Our anti-EPHX2 recombinant antibodies are designed with the utmost specificity and performance in mind. They are rigorously validated to detect the sEH enzyme specifically in a variety of tissues, including vasculature, kidney, and liver. Optimized for use in applications such as Western Blot to measure expression levels or IHC to visualize localization, our rAbs will deliver the performance you need in pharmacology.

Table 1. Featured anti-EPHX2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs develops products specifically for the unique and demanding needs of the pharmacology field. Our anti-EPHX2 recombinant antibodies are expressed in optimized systems designed to ensure your antibody will accurately recognize the native target, providing you with a specific and active reagent for even your most challenging experiments.

Featured Anti-EPHX2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-EPHX2 recombinant antibody production.

Fig.2 Gram-scale anti-EPHX2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific breakthroughs by developing and delivering versatile antibody solutions. Our anti-EPHX2 recombinant antibodies can be customized in a number of different formats to meet your experimental needs, helping scientists around the world to study this important enzyme.

Fig.3 Full-length anti-EPHX2 recombinant antibody production and modalities.

Explore the complexities of lipid signaling with the ultra-specificity of Creative Biolabs' anti-EPHX2 recombinant antibodies. Our validated, lot-to-lot consistent products will give you the solid foundation you need to study this important therapeutic target in cardiovascular and inflammatory disease. Contact our scientific team today.