


ERLIN2

Anti-ERLIN2 Products
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, IF
- Anti-ERLIN2 Immunohistochemistry Kit (VS-0525-XY2353)
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- Species Reactivity: Human
- Target: ERLIN2
- Application: IHC
- Anti-Mouse ERLIN2 Immunohistochemistry Kit (VS-0525-XY2354)
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- Species Reactivity: Human, Mouse
- Target: ERLIN2
- Application: IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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For Research Use Only. Not For Clinical Use.
Background
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 (PubMed:19240031, PubMed:21610068). Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination (By similarity). Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex (PubMed:24217618). Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139 (PubMed:21343306). Interacts with TMEM259 (By similarity). Interacts with TMEM41B (PubMed:30352685).