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ERN1
Anti-ERN1 Recombinant Antibody Products
- Mouse Anti-ERN1 Recombinant Antibody (clone 9F2) (VS7-HM899)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC-p, IF, ELISA
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- Chicken Anti-IRE1A Polyclonal IgY (BRD-0752MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ELISA, IP, WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (Karpas-707, RPMI-8226, U-266/70)
Interaction
Monomer (PubMed:29198525, PubMed:16973740). Homodimer; disulfide-linked; homodimerization takes place in response to endoplasmic reticulum stress and promotes activation of the kinase and endoribonuclease activities (PubMed:12637535, PubMed:24508390, PubMed:16973740, PubMed:21317875). Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges (PubMed:12637535). Interacts (via the luminal region) with DNAJB9/ERdj4; interaction takes place in unstressed cells and promotes recruitment of HSPA5/BiP (PubMed:29198525). Interacts (via the luminal region) with HSPA5/BiP; HSPA5/BiP is a negative regulator of the unfolded protein response (UPR) that prevents homodimerization of ERN1/IRE1 and subsequent activation of the protein (PubMed:12637535, PubMed:29198525). Interacts with PDIA6, a negative regulator of the UPR; the interaction is direct and disrupts homodimerization (PubMed:24508390). Interacts with DAB2IP (via PH domain); the interaction occurs in a endoplasmic reticulum stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1/IRE1 (By similarity). Interacts with TAOK3 and TRAF2 (PubMed:11278723). Interacts with RNF13 (PubMed:23378536). Interacts with LACC1 (PubMed:31875558). Interacts (when unphosphorylated) with DDRGK1; interaction is dependent on UFM1 and takes place in response to endoplasmic reticulum stress, regulating ERN1/IRE1-alpha stability (PubMed:28128204).
Molecular function
Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase
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