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Ebi3
EBI3 was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.
Predicted location
Secreted
Single cell type specificity
Group enriched (monocytes, Extravillous trophoblasts, Syncytiotrophoblasts)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell, non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enriched (HDLM-2)
Interaction
Heterodimer with IL27/IL27A; not disulfide-linked (PubMed:12121660). This heterodimer is known as interleukin IL-27 (PubMed:12121660). Heterodimer with IL12A; not disulfide-linked (PubMed:9342359). This heterodimer is known as interleukin IL-35 (PubMed:9342359). Interacts with SQSTM1 (PubMed:8551575).
Molecular function
Cytokine
More Types Infomation
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- Species Reactivity: Mouse
- Type: Mouse IgG3, κ
- Application: WB, Neut
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- Species Reactivity: Mouse
- Type: Mouse IgG2b
- Application: ELISA, Neut, WB, IP
- Mouse Anti-EBI3 Recombinant Antibody; Fab Fragment (MOB-206YJL-F(E)) (MOB-206YJL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-EBI3 Recombinant Antibody; scFv Fragment (MOB-206YJL-S(P)) (MOB-206YJL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
- Mouse Anti-EBI3 Recombinant Antibody (MOB-206YJL) (MOB-206YJL)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.