Enrofloxacin is a fluoroquinolone that inhibits the activity of bacterial DNA gyrase. It was the first fluoroquinolone antimicrobial to be used in veterinary medicine and is indicated in therapy of infections by E. coli, Salmonella, Pasteurella, Mycoplasma and Hemophilus species. In the USA, approved use is currently limited to dogs, but approval for use in food-animals is under consideration.