Anti-F12 Recombinant Antibody Products

Loading...

Anti-F12 Products

+ Filter

Loading...

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Explore hematology and inflammation research with our high-affinity anti-F12 recombinant antibodies from Creative Biolabs. As the initiator of the intrinsic coagulation pathway, Coagulation Factor XII (F12) is a novel target for therapeutics with the potential to simultaneously block thrombosis and inflammation. Our high-quality recombinant antibodies are valuable reagents for studies of the contact system and drug development for thrombosis and hereditary angioedema (HAE).

F12: An Initiator of Thrombosis and Inflammation

Coagulation Factor XII (F12), also known as Hageman factor, is a plasma protease that auto-activates after binding to negatively charged surfaces. The active enzyme (F12a) has two main functions: 1) It activates Factor XI and initiates the intrinsic coagulation pathway in a manner that has been primarily associated with pathogenic thrombosis (e.g., medical device-related thrombosis). 2) It activates the kallikrein-kinin system by proteolytic cleavage of prekallikrein to kallikrein, which in turn cleaves high-molecular weight kininogen to release the pro-inflammatory peptide bradykinin. F12’s dual role in thrombosis and inflammation makes it a prime target for therapeutics that might prevent both processes, without affecting physiological hemostasis. F12 has a key advantage over other targets: Genetic deficiency of F12 is not associated with bleeding.

Alternative Names

Coagulation Factor XII; Hageman Factor; EC 3.4.21.38; HAF; Coagulation Factor XII (Hageman Factor); Coagulation Factor XIIa Heavy Chain; Coagulation Factor XIIa Light Chain;

Background

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

Anti-F12 rAb Products

Our anti-F12 recombinant antibodies were developed for high affinity and potent neutralizing activity. They were carefully validated to ensure that they can be used to accurately detect F12, as well as block F12 activation or enzymatic activity. Our rAbs have been optimized for use in applications such as ELISA, functional coagulation assays and functional bradykinin-generation assays, to provide you with a consistent, highly specific, active reagent for your research and drug discovery efforts.

Table 1. Featured anti-F12 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

D**re
Human Anti-F12 Recombinant Antibody (HPAB-2293LY)

The quality of Creative Biolabs’ antibodies is consistently high. Their anti-F12 antibody has worked without issue, which is critical for our studies of this clinically important drug target.

17/Nov/2022

rAb Production

Creative Biolabs’ state-of-the-art recombinant antibody production platforms are designed to meet the specialized needs of hematology research. Our anti-F12 recombinant antibodies are produced using systems that have been optimized to accurately recognize the native enzyme form, which ensures you will receive a highly specific and active reagent for your research.

Featured Anti-F12 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-F12 recombinant antibody production.

Fig.2 Gram-scale anti-F12 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting scientific discovery by providing flexible antibody solutions. Our anti-F12 recombinant antibodies are available in multiple modalities, including potent functional blocking clones.

Fig.3 Full-length anti-F12 recombinant antibody production and modalities.

F12-Targeted Drug Information

Table 2. Public drug targeting F12.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Investigate F12’s role in thrombosis and inflammation with high-affinity recombinant antibodies from Creative Biolabs. Our selection of high-quality, functional antibodies provides the potency and validation you need to develop novel therapeutics for HAE and thrombosis. Partner with Creative Biolabs to power your important research today. Contact our scientific team now.