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FES
Loading...Anti-FES Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-FES Recombinant Antibody (VS3-FY2704) (VS3-FY2704)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IHC
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- Recombinant Mouse Anti-Human FES Antibody (MOB-1991MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-FES Recombinant Antibody (clone 121-15B10) (EPAF-0196LC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: Block, ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC-p, IF, ELISA
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- Anti-FES Immunohistochemistry Kit (VS-0525-XY2506)
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- Species Reactivity: Human
- Target: FES
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Kupffer cells, monocytes, Macrophages, Hofbauer cells, Adipocytes)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (HEL, HL-60, HMC-1, NB-4, THP-1, U-937)
Interaction
Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
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