Mouse Anti-FES Recombinant Antibody (VS3-FY2704) (CAT#: VS3-FY2704)
This exceptional mouse recombinant monoclonal antibody showcases a superior level of effectiveness in its interaction with FES. The calculated molecular weight of the antigen is 93.5 kDa. It shows capability of cross-reacting with human and mouse. This monoclonal antibody is potential for conducting research on Sarcoma and Myeloid Leukemia. This monoclonal antibody can be used in Western Blot, Immunohistochemistry.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/59_E5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/59_E5_1_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subset of germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_4_8_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subset of germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_4_8_selected.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_6_6.jpg
Figure 6 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182511-FES
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182511-FES
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- FES proto-oncogene, tyrosine kinase of human and mouse origins
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 93.5 kDa.
- Related Disease
- Sarcoma and Myeloid Leukemia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Target
- Alternative Names
- FES Proto-Oncogene, Tyrosine Kinase; Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog; Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog; Oncogene FES, Feline Sarcoma Virus; Feline Sarcoma Oncogene; Proto-Oncogene C-Fes; Proto-Oncogene C-Fps; EC 2.7.10.2
- Gene ID
- 2242
- UniProt ID
- P07332
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
- Cellular Localization
- Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cell membrane; Peripheral membrane protein; Cytoplasmic side
Cytoplasmic vesicle
Golgi apparatus
Cell junction, focal adhesion
- Post Translation Modifications
- Autophosphorylated on Tyr-713.
Phosphorylated by LYN in response to FCER1 activation.
Phosphorylated by HCK.
Ubiquitination at Lys725
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_005254937.1; XP_005254939.1; XP_016877494.1; XP_016877495.1; XP_016877496.1
- Function
- Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.
Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.
Plays a role in the regulation of mast cell degranulation.
Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling.
Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR.
Phosphorylates BCR and down-regulates BCR kinase activity.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Please select product type
IgG Antibody Products
Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1991MZ | Recombinant Mouse Anti-Human FES Antibody | WB | Mouse antibody |
| ZG-0341J | Mouse Anti-FES Recombinant Antibody (ZG-0341J) | WB, ELISA | Mouse IgG |
| ZG-0342J | Mouse Anti-FES Recombinant Antibody (ZG-0342J) | WB, IHC, ELISA | Mouse IgG |
| VS3-QX423 | Mouse Anti-FES Recombinant Antibody (clone 5A11G5) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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