Mouse Anti-FES Recombinant Antibody (VS3-FY2704) (CAT#: VS3-FY2704)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• FES proto-oncogene, tyrosine kinase of human and mouse origins

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 93.5 kDa.

• Related Disease
• Sarcoma and Myeloid Leukemia

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200

• Alternative Names
• FES Proto-Oncogene, Tyrosine Kinase; Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog; Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog; Oncogene FES, Feline Sarcoma Virus; Feline Sarcoma Oncogene; Proto-Oncogene C-Fes; Proto-Oncogene C-Fps; EC 2.7.10.2

• Gene ID
• 2242

• UniProt ID
• P07332

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

• Cellular Localization
• Cytoplasm, cytosol
  Cytoplasm, cytoskeleton
  Cell membrane; Peripheral membrane protein; Cytoplasmic side
  Cytoplasmic vesicle
  Golgi apparatus
  Cell junction, focal adhesion

• Post Translation Modifications
• Autophosphorylated on Tyr-713.
  Phosphorylated by LYN in response to FCER1 activation.
  Phosphorylated by HCK.
  Ubiquitination at Lys725
  Modification sites at PhosphoSitePlus

• Protein Refseq
• XP_005254937.1; XP_005254939.1; XP_016877494.1; XP_016877495.1; XP_016877496.1

• Function
• Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.
  Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.
  Plays a role in the regulation of mast cell degranulation.
  Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling.
  Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR.
  Phosphorylates BCR and down-regulates BCR kinase activity.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Select a product category from the dropdown menu below to view related products.