Mouse Anti-FES Recombinant Antibody (VS3-FY2704)
CAT#: VS3-FY2704
This exceptional mouse recombinant monoclonal antibody showcases a superior level of effectiveness in its interaction with FES. The calculated molecular weight of the antigen is 93.5 kDa. It shows capability of cross-reacting with human and mouse. This monoclonal antibody is potential for conducting research on Sarcoma and Myeloid Leukemia. This monoclonal antibody can be used in Western Blot, Immunohistochemistry.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/59_E5_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subset of germinal center cells and non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_4_8_selected.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1376/169745_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HEL, HL-60, HMC-1, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182511-FES
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- FES proto-oncogene, tyrosine kinase of human and mouse origins
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 93.5 kDa.
- Related Disease
- Sarcoma and Myeloid Leukemia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Target
- Alternative Names
- FES Proto-Oncogene, Tyrosine Kinase; Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog; Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog; Oncogene FES, Feline Sarcoma Virus; Feline Sarcoma Oncogene; Proto-Oncogene C-Fes; Proto-Oncogene C-Fps; EC 2.7.10.2
- Gene ID
- 2242
- UniProt ID
- P07332
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
- Cellular Localization
- Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cell membrane; Peripheral membrane protein; Cytoplasmic side
Cytoplasmic vesicle
Golgi apparatus
Cell junction, focal adhesion
- Post Translation Modifications
- Autophosphorylated on Tyr-713.
Phosphorylated by LYN in response to FCER1 activation.
Phosphorylated by HCK.
Ubiquitination at Lys725
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_005254937.1; XP_005254939.1; XP_016877494.1; XP_016877495.1; XP_016877496.1
- Function
- Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.
Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.
Plays a role in the regulation of mast cell degranulation.
Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling.
Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR.
Phosphorylates BCR and down-regulates BCR kinase activity.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FES"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1991MZ | Recombinant Mouse Anti-Human FES Antibody | WB | Mouse antibody |
| ZG-0341J | Mouse Anti-FES Recombinant Antibody (ZG-0341J) | WB, ELISA | Mouse IgG |
| ZG-0342J | Mouse Anti-FES Recombinant Antibody (ZG-0342J) | WB, IHC, ELISA | Mouse IgG |
| VS7-HM941 | Mouse Anti-FES Recombinant Antibody (clone CBL279HM) | WB, IHC-p, IF, ELISA | Mouse IgG |
| VS7-HM942 | Mouse Anti-FES Recombinant Antibody (clone CBL280HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1284 | Hi-Affi™ Rabbit Anti-FES Recombinant Antibody (clone DS1284AB) | FC, ICC, IF, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0196LC | Mouse Anti-FES Recombinant Antibody (clone 121-15B10) | Block, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2506 | Anti-FES Immunohistochemistry Kit | IHC |
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