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    FOXA1

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    Anti-FOXA1 Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
    FOXA1
    Protein class

    Cancer-related genes, Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Urothelial cells, Basal prostatic cells, Prostatic glandular cells, Breast glandular cells, Enteroendocrine cells, Basal squamous epithelial cells, Respiratory ciliated cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (Hep G2, MCF7, PC-3, RT4, SK-BR-3, T-47d)

    Interaction

    Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).

    Molecular function

    Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor

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